Targeting IL-25 as a novel therapy in chronic rhinosinusitis with nasal polyps

Current Opinion in Allergy & Clinical Immunology:

February 2017 - Volume 17 - Issue 1 - p 17–22

doi: 10.1097/ACI.0000000000000332

RHINITIS, SINUSITIS AND UPPER AIRWAY DISEASE: Edited by Ruby Pawankar and David P. Skoner

Lee, Mingyu; Kim, Dae Woo; Shin, Hyun-Woo

Open Access

Abstract

Purpose of review: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous inflammatory disorder with a poorly understood pathophysiology. Recent findings show that epithelial-derived cytokines, including thymic stromal lymphopoietin, IL-33, and IL-25, can exacerbate Th2 immune responses, ultimately leading to recalcitrant chronic rhinosinusitis and nasal polyps. Although IL-25 is increased in CRSwNP, the targeting of IL-25 as a therapeutic strategy remains largely unexplored. In this review, we outline the many recent advances in our understanding of the association between IL-25 and CRSwNP.

Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid

Clinical and Translational Allergy

LETTER TO THE EDITOR

 

OPEN ACCESS

• Nicolaj Brandt,
• Lene H. Garvey,
• Ulla Bindslev-Jensen,
• Henrik Fomsgaard Kjaer,
• Carsten Bindslev-Jensen and
• Charlotte G. MortzEmail authorView ORCID ID profile

Clinical and Translational Allergy20177:2

DOI: 10.1186/s13601-016-0138-3

Abstract

We present three cases with anaphylaxis after injection of a depot corticosteroid. First, the steroid was suspected as the elicitor, but after evaluation the excipient macrogol was found to be the elicitor.

Adult Food Allergy Prevalence: Reducing Questionnaire Bias.

Vol. 171, No. 3-4, 2016
Issue release date: Published online first
Section title: Original Paper

Free Supplementary Material Int Arch Allergy Immunol 2016;171:261-264  (DOI:10.1159/000453036) Silva L.A. · Silva A.F.M. · Ribeiro Â.C. · Silva A.O. · Vieira F.A. · Segundo G.R.S.  Allergy and Immunology Division, Pediatrics Department, Universidade Federal de Uberlandia, Uberlandia, Brazil  Corresponding Author

• Abstract
• FullText
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Abstract

Background: Food allergy (FA) prevalence has increased in the last decades, but epidemiologic studies could show overestimated results. The objective of this study is to estimate the prevalence of immediate FA in adults in a region of Central Brazil, using a questionnaire to try to reduce misperceptions about FA reaction. 

The ingestion of cow's milk formula in the first 3 months of life prevents the development of cow's milk allergy

• Asia Pac Allergy
• v.6(4); 2016 Oct
• PMC5088256

Asia Pac Allergy. 2016 Oct; 6(4): 207–212.

Published online 2016 Oct 31. doi:  10.5415/apallergy.2016.6.4.207

PMCID: PMC5088256

Tetsuhiro Sakihara,1,2 Shiro Sugiura,1 and Komei Ito1

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Abstract

Background

IgE-mediated cow's milk allergy (CMA) is one of the most common food allergies in infants. It is still controversial whether the early introduction of cow's milk formula (CMF) prevents the development of CMA.

Objective

We aimed to evaluate the duration and frequency of CMF ingestion as compere with exclusive breast-fed for preventing CMA in high-risk infants.

Innate and adaptive immune traits are differentially affected by genetic and environmental factors

• Massimo Mangino
• , Mario Roederer
• , Margaret H. Beddall
• , Frank O. Nestle
•  & Tim D. Spector
• • Article | OPEN
  • • • 
        
      • Nature Communications 8, Article number: 13850 (2017)
      • doi:10.1038/ncomms13850
      • • • • 
              
            • • Abstract
                The diversity and activity of leukocytes is controlled by genetic and environmental influences to maintain balanced immune responses. However, the relative contribution of environmental compared with genetic factors that affect variations in immune traits is unknown. Here we analyse 23,394 immune phenotypes in 497 adult female twins. 76% of these traits show a predominantly heritable influence, whereas 24% are mostly influenced by environment.

Complementary Feeding: A Position Paper by the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) Committee on Nutrition

Fewtrell, Mary; Bronsky, Jiri; Campoy, Cristina; Domellöf, Magnus; Embleton, Nicholas; Fidler Mis, Nataša; Hojsak, Iva; Hulst, Jessie M.; Indrio, Flavia; Lapillonne, Alexandre; Molgaard, Christian

Journal of Pediatric Gastroenterology and NutritionJanuary 2017Vol. 64 - Issue 1: p 119–132

Abstract

This position paper on complementary feeding summarizes evidence for health effects of complementary foods. It focuses on healthy infants in Europe. After reviewing current knowledge and practices, we have formulated these conclusions: Exclusive or full breast-feeding for about 6 months is a desirable goal. Complementary feeding (ie, solid foods and liquids other than breast milk or infant formula and follow-on formula) should not be introduced before 17 weeks and not later than 26 weeks.

ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle

J. Bousquet, P. W. Hellings, I. Agache, A. Bedbrook, C. Bachert, K. C. Bergmann, M. Bewick, C. Bindslev-Jensen, S. Bosnic-Anticevitch, C. Bucca, D. P. Caimmi, P. A. M. Camargos, G. W. Canonica, T. Casale, N. H. Chavannes et al.

Open Access Review

Abstract

The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA—disseminated and implemented in over 70 countries globally—is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves.

Allergy immunotherapy across the life cycle to promote active and healthy ageing: from research to policies

• Clin Transl Allergy
• v.6; 2016
• PMC5120439

Clin Transl Allergy. 2016; 6: 41.

An AIRWAYS Integrated Care Pathways (ICPs) programme item (Action Plan B3 of the European Innovation Partnership on active and healthy ageing) and the Global Alliance against Chronic Respiratory Diseases (GARD), a World Health Organization GARD research demonstration project

M. A. Calderon,1 P. Demoly,2 T. Casale,3 C. A. Akdis,4 C. Bachert,5 M. Bewick,6 B. M. Bilò,7 B. Bohle,8 S. Bonini,9 A. Bush,1 D. P. Caimmi,2 G. W. Canonica,10 V. Cardona,11 A. M. Chiriac,12 L. Cox,13 A. Custovic,1 F. De Blay,14 P. Devillier,15 A. Didier,16 G. Di Lorenzo,17 G. Du Toit,18 S. R. Durham,19 P. Eng,20 A. Fiocchi,21 A. T. Fox,22 R. Gerth van Wijk,23 R. M. Gomez,24 T. Haathela,25 S. Halken,26 P. W. Hellings,27 L. Jacobsen,28 J. Just,29 L. K. Tanno,30,31,32 J. Kleine-Tebbe,33 L. Klimek,34 E. F. Knol,35 P. Kuna,36 D. E. Larenas-Linnemann,37,38 A. Linneberg,39,40,41 M. Matricardi,42 H. J. Malling,43 R. Moesges,44 J. Mullol,45 A. Muraro,46 N. Papadopoulos,47 G. Passalacqua,48 E. Pastorello,49 O. Pfaar,50,51,52 D. Price,53,54,55 P. Rodriguez del Rio,56 R. Ruëff,57 B. Samolinski,58 G. K. Scadding,59,60 G. Senti,61 M. H. Shamji,62,63 A. Sheikh,64 J. C. Sisul,65 D. Sole,66 G. J. Sturm,67,68 A. Tabar,69 R. Van Ree,70 M. T. Ventura,71 C. Vidal,72 E. M. Varga,73 M. Worm,74 T. Zuberbier,74 and J. Bousquet31,75,76,77,78

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Abstract

Allergic diseases often occur early in life and persist throughout life. This life-course perspective should be considered in allergen immunotherapy. In particular it is essential to understand whether this al treatment may be used in old age adults.