February 10, 2017

High-dose anti-histamine use and risk factors in children with urticaria


Pınar Uysal 1 ,  Sibelnur Avcil 2 ,  Duygu Erge 1 
1 Adnan Menderes Üniversitesi Tıp Fakültesi, Çocuk Allerji ve Klinik İmmunoloji Bilim Dalı, Aydın, Türkiye 
2 Adnan Menderes Üniversitesi Tıp Fakültesi, Çocuk ve Ergen Ruh Sağlığı ve Hastalıkları Anabilim Dalı, Aydın, Türkiye 


Abstract
Aim: The drugs of choice in the treatment of urticaria in children are H1-antihistamines. The aim of the study was to evaluate children with urticaria and define risk factors for requirement of high-dose H1-antihistamines in children with urticaria.

February 9, 2017

Revisiting Type 2-high and Type 2-low airway inflammation in asthma: current knowledge and therapeutic implications

  • DOI: 10.1111/cea.12880View/save citation 
  • Summary
    Asthma is a complex respiratory disorder characterized by marked heterogeneity in individual patient disease triggers and response to therapy. Several asthma phenotypes have now been identified, each defined by a unique interaction between genetic and environmental factors, including inflammatory, clinical and trigger-related phenotypes.

Subtypes of asthma based on asthma control and severity: a latent class analysis

 
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  • Elina M. S. Mäkikyrö,
  • Maritta S. Jaakkola and
  • Jouni J. K. JaakkolaEmail author
Abstract
Background
Asthma subtyping is a complex new field of study. Usually both etiological and outcome factors of asthma have been used simultaneously for subtyping thus making the interpretation of the results difficult. Identification of subtypes of asthma based on questionnaire data only will be useful for both treatment of asthma and for research. Our objective was to identify asthma subtypes that capture both asthma control and severity based on easily accessible variables.

February 7, 2017

The current and future role of biomarkers in type 2 cytokine-mediated asthma management

Review
I. D. Pavord, S. Afzalnia, A. Menzies-Gow, L. G. Heaney

Summary

Assessment and management of asthma is complicated by the heterogeneous pathophysiological mechanisms that underlie its clinical presentation, which are not necessarily reflected in standardized management paradigms and which necessitate an individualized approach to treatment. This is particularly important with the emerging availability of a variety of targeted forms of therapy that may only be appropriate for use in particular patient subgroups. The identification of biomarkers can potentially aid diagnosis and inform prognosis, help guide treatment decisions and allow clinicians to predict and monitor response to treatment.

February 6, 2017

Effects of low-dose clarithromycin added to fluticasone on inflammatory markers and pulmonary function among children with asthma: A randomized clinical trial

Abstract:
Background: 

Macrolides exert anti-inflammatory and immunomodulatory effects beyond 
their purely antibacterial action, as demonstrated by several bronchial inflammatory disorders, including asthma. 

February 4, 2017

Adult Food Allergy Prevalence: Reducing Questionnaire Bias


Silva L.A. · Silva A.F.M. · Ribeiro Â.C. · Silva A.O. · Vieira F.A. · Segundo G.R.S. 
Allergy and Immunology Division, Pediatrics Department, Universidade Federal de Uberlandia, Uberlandia, Brazil
email Corresponding Author


Abstract

Background: Food allergy (FA) prevalence has increased in the last decades, but epidemiologic studies could show overestimated results. The objective of this study is to estimate the prevalence of immediate FA in adults in a region of Central Brazil, using a questionnaire to try to reduce misperceptions about FA reaction. 

Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection



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Abstract

Rhinovirus is a common cause of upper and lower respiratory tract infections in adults, especially among the elderly and immunocompromised. Nevertheless, its clinical characteristics and mortality risks have not been well described. A retrospective analysis on a prospective cohort was conducted in a single teaching hospital center over a one-year period. We compared adult patients hospitalized for pneumonia caused by rhinovirus infection with those hospitalized for influenza infection during the same period. All recruited patients were followed up for at least 3 months up to 15 months. Independent risk factors associated with mortality for rhinovirus infection were identified.