Thyroid Autoimmunity: Role of Anti-thyroid Antibodies in Thyroid and Extra-Thyroidal Diseases

09 May 2017 | https://doi.org/10.3389/fimmu.2017.00521

Eleonore Fröhlich1,2 and Richard Wahl1*

1Internal Medicine (Department of Endocrinology and Diabetology, Angiology, Nephrology and Clinical Chemistry), University of Tuebingen, Tuebingen, Germany 2Center for Medical Research, Medical University Graz, Graz, Austria

Autoimmune diseases have a high prevalence in the population, and autoimmune thyroid disease (AITD) is one of the most common representatives. Thyroid autoantibodies are not only frequently detected in patients with AITD but also in subjects without manifest thyroid dysfunction. The high prevalence raises questions regarding a potential role in extra-thyroidal diseases. This review summarizes the etiology and mechanism of AITD and addresses prevalence of antibodies against thyroid peroxidase, thyroid-stimulating hormone receptor (TSHR), and anti-thyroglobulin and their action outside the thyroid.

Quality indicators for the acute and long-term management of anaphylaxis: a systematic review

Clinical and Translational Allergy

• Sangeeta DhamiView ORCID ID profile,
• Aadam Sheikh,
• Antonella Muraro,
• Graham Roberts,
• Susanne Halken,
• Monserat Fernandez Rivas,
• Margitta Worm and
• Aziz SheikhEmail author

Clinical and Translational Allergy20177:15

DOI: 10.1186/s13601-017-0151-1

Abstract

Background

The quality of acute and long-term anaphylaxis management is variable and this contributes to the poor outcomes experienced by many patients. Clinical practice guidelines have the potential to improve outcomes, but implementing guideline recommendations in routine practice is challenging. Quality indicators have the potential to support guideline implementation efforts.

Multicentre, non-interventional study to assess the profile of patients with uncontrolled rhinitis prescribed a novel formulation of azelastine hydrochloride and fluticasone propionate in a single spray in routine clinical practice in the UK

Respiratory medicine

Research

Glenis Scadding, David Price, Tariq El-Shanawany, Shahzada Ahmed, Jaydip Ray, Ravishankar Sargur, Nirmal Kumar

Abstract

Objective The aims of this study were (1) to characterise the type of patient prescribed MP-AzeFlu (Dymista, a novel formulation of azelastine hydrochloride, fluticasone propionate and excipients in a single spray) in real life in the UK and physicians' reasons for prescribing it and (2) to quantify the personal and societal burden of allergic rhinitis (AR) in the UK prior to MP-AzeFlu prescription.

IgE-mediated food allergies in children: prevalence, triggers, and management

REVIEW ARTICLE

Korean J Pediatr 2017 April;60(4) :99-105. Published online 2017 April 15.

Sooyoung Lee Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea Corresponding Author: Sooyoung Lee ,Tel: +82-31-219-5160, Fax: +82-31-219-5169, Email: jsjs87@ajou.ac.kr ABSTRACT Food allergy (FA) is a serious health problem, and severe FA such as food-induced anaphylaxis can often be life threatening. The incidence of FA has been increasing especially in children. They usually develop early in life and affect up to 10% of children. The 2 most common food allergens worldwide are milk and eggs, while the third one varies depending on the countries: peanuts in the United States and Switzerland, wheat in Germany and Japan, tree nuts in Spain, sesame in Israel, and walnuts in Korea.

Spotlight on dupilumab in the treatment of atopic dermatitis: design, development, and potential place in therapy

Drug Design, Development and Therapy. Volume 11

Angelo Massimiliano D’Erme,^1,2 Marco Romanelli,² Andrea Chiricozzi<sup>2

1</sup>Dermatology Unit, Livorno Hospital, Livorno, ²Dermatology Unit, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy

Abstract: Atopic dermatitis (AD) is among the most common inflammatory skin diseases in children and adults in industrialized countries. Up to one-third of adults (probably a smaller proportion in childhood) suffer from moderate-to-severe AD, whose recommended treatment is usually based on systemic therapies. The currently available therapeutics are limited, and AD management becomes challenging in most cases.

Searching online for health-related information by people suffering from respiratory allergy and asthma: the results of a survey study

Anna Kłak, Filip Raciborski, Bolesław Samoliński

DOI: 10.5603/ARM.2017.0015·Adv Respir Med 2017;85(2):87-96.

Abstract

INTRODUCTION:

The objective of the study was to compare online behaviour in groups of persons suffering from respiratory allergy and/or asthma and in the reference group.

Association of Oral Antireflux Medication With Laryngopharyngeal Reflux and Nasal Resistance

JAMA Otolaryngology

Original Investigation

May 2017

Elif Dagli, MD¹; Alper Yüksel, MD²; Mesut Kaya, MD²; et alKadriye Serife Ugur²; Fatma Cansel Turkay³

Author Affiliations

JAMA Otolaryngol Head Neck Surg. 2017;143(5):478-483. doi:10.1001/jamaoto.2016.4127

Key Points

Question  Is laryngopharyngeal reflux associated with nasal resistance, and does pharmacologic therapy improve subjective and objective nasal findings?

Findings  This case-control study of 100 adults (50 with laryngopharyngeal reflux, 50 controls) found that oral antireflux medication was associated with significant decreases in all parameters of the Nasal Obstruction Symptom Evaluation and Total Nasal Resistance values.

eHealth in the future of medications management: personalisation, monitoring and adherence

BMC Medicine 

OPINION

 

OPEN ACCESS

 

OPEN PEER REVIEW

• Josip CarEmail authorView ORCID ID profile,
• Woan Shin Tan,
• Zhilian Huang,
• Peter Sloot and
• Bryony Dean Franklin

BMC Medicine201715:73

DOI: 10.1186/s12916-017-0838-0

Abstract

Background

Globally, healthcare systems face major challenges with medicines management and medication adherence. Medication adherence determines medication effectiveness and can be the single most effective intervention for improving health outcomes.