Adverse drug reactions of montelukast in children and adults

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Volume 5, Issue 5
October 2017
e00341

• Open Access
• Creative Commons

Original Article

Authors

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• First published: 20 September 2017Full publication history
• DOI: 10.1002/prp2.341  View/save citation
• Cited by (CrossRef): 0 articlesCheck for updates
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• Principal Investigator: Tjalling W de Vries MD PhD

Abstract

Montelukast, a selective leukotriene receptor antagonist, is recommended in guidelines for the treatment of asthma in both children and adults. However, its effectiveness is debated, and recent studies have reported several adverse events such as neuropsychiatric disorders and allergic granulomatous angiitis.

Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis

Mirabelli C, Scheers E and Neyts J. Novel therapeutic approaches to simultaneously target rhinovirus infection and asthma/COPD pathogenesis [version 1; referees: 2 approved]. F1000Research 2017, 6(F1000 Faculty Rev):1860 (doi: 10.12688/f1000research.11978.1)

Abstract

Rhinoviruses are exclusive respiratory pathogens and the etiological agents of the common cold. These viruses are increasingly reported to cause exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Here, we review the role of rhinovirus infections in the pathogenesis of asthma and COPD and we discuss the current and potential future treatments. We propose that, in order to prevent exacerbations, the design of novel therapeutics should focus on directly acting antivirals but also include the design of drugs that simultaneously inhibit viral replication and alleviate symptoms of asthma and COPD.

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Virus-triggered exacerbation in allergic asthmatic children: neutrophilic airway inflammation and alteration of virus sensors characterize a subgroup of patients

RESEARCH

 

OPEN ACCESS

• Antoine DeschildreEmail author,
• Muriel Pichavant,
• Ilka Engelmann,
• Carole Langlois,
• Elodie Drumez,
• Guillaume Pouessel,
• Sophie Boileau,
• David Romero-Cubero,
• Irina Decleyre-Badiu,
• Anny Dewilde,
• Didier Hober,
• Véronique Néve,
• Caroline Thumerelle,
• Stéphanie Lejeune,
• Clémence Mordacq and
• Philippe GossetEmail authorView ORCID ID profile

Respiratory Research201718:191

https://doi.org/10.1186/s12931-017-0672-0

©  The Author(s). 2017

Abstract

Background

Viruses are important triggers of asthma exacerbations. They are also detected outside of exacerbation. Alteration of anti-viral response in asthmatic patients has been shown although the mechanisms responsible for this defect remain unclear. The objective of this study was to compare in virus-infected and not-infected allergic asthmatic children, aged 6 to 16 years, admitted to hospital for a severe exacerbation, the innate immune response and especially the expression of pattern recognition receptor (PRR) and their function.

Effect of an Intervention to Promote Breastfeeding on Asthma, Lung Function, and Atopic Eczema at Age 16 Years

Carsten Flohr, MD, PhD¹; A. John Henderson, MD²; Michael S. Kramer, MD³; et alRita Patel, PhD²; Jennifer Thompson, MPP⁴; Sheryl L. Rifas-Shiman, MPH⁴; Seungmi Yang, PhD^3,5; Konstantin Vilchuck, MD⁶; Natalia Bogdanovich, MD⁶; Mikhail Hameza⁶; Richard M. Martin, BMBS, PhD^2,7; Emily Oken, MD, MPH⁴

Author Affiliations Article Information

JAMA Pediatr. Published online November 13, 2017. doi:10.1001/jamapediatrics.2017.4064

Key Points

Question  Does prolonged and exclusive breastfeeding reduce the risk of asthma and atopic eczema and improve lung function in adolescence?

Extent and consequences of inadequate disease control among adults with a history of moderate to severe atopic dermatitis

Original Article

Authors

• Wenhui Wei,Peter Anderson, Abhijit Gadkari, Stuart Blackburn, Rachel Moon, James Piercy, Shashank Shinde, Jorge Gomez, Eric Ghorayeb

• DOI: 10.1111/1346-8138.14116  View/save citation
• Abstract

  Since control of atopic dermatitis (AD) remains challenging but has not been adequately characterized, the objective of this study was to characterize disease control among patients with a history of moderate to severe AD.