Epinephrine in Anaphylaxis: Preclinical Study of Pharmacokinetics after Sublingual Administration of Taste-Masked Tablets for Potential Pediatric Use

Open Access

Pharmaceutics 2018, 10(1), 24; doi:10.3390/pharmaceutics10010024

Ousama Rachid 1,*, Mutasem Rawas-Qalaji 2,* and Keith J. Simons 3

Abstract

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Epinephrine is a life-saving treatment in anaphylaxis. In community settings, a first-aid dose of epinephrine is injected from an auto-injector (EAI). Needle phobia highly contributes to EAI underuse, leading to fatalities—especially in children. A novel rapidly-disintegrating sublingual tablet (RDST) of epinephrine was developed in our laboratory as a potential alternative dosage form.

CSACI position statement: prescribing sublingual immunotherapy tablets for aeroallergens

Allergy, Asthma & Clinical Immunology Review Open Access

J. Quirt,

R. Gagnon,

A. K. Ellis and

H. L. Kim

• Email author

Allergy, Asthma & Clinical Immunology201814:1

https://doi.org/10.1186/s13223-017-0225-6

Background: Allergic rhinitis is estimated to affect 20–25% of Canadians and has a significant impact on quality of life, with many patients reporting inadequate control of their symptoms [1]. Mainstays of treatment for allergic rhinitis include avoidance, intranasal steroids, oral antihistamines and leukotriene receptor antagonists [2]. Specific immunotherapy offers disease-modifying treatment for those uncontrolled by, intolerant to, or averse to pharmacotherapy [3]. 

Heterogeneous pattern of differences in respiratory parameters between elderly with either good or poor FEV1

BMC Pulmonary Medicine

Research article

Open Access

Open Peer Review

• Stefan KarraschEmail author,
• Jürgen Behr,
• Rudolf M. Huber,
• Dennis Nowak,
• Annette Peters,
• Stefan Peters,
• Rolf Holle,
• Rudolf A. Jörres,
• Holger Schulz and
• KORA Study Group

BMC Pulmonary MedicineBMC series – open, inclusive and trusted201818:27

https://doi.org/10.1186/s12890-018-0582-z

Open Peer Review reports

Abstract

Background: The relationship of spirometric values to other respiratory and functional parameters in advanced age is not well studied.

Dr. Jay Portnoy describes how to perform a systematic review to answer questions

ACAAICOLA

Dr. Sharon Jacob discusses pediatric contact dermatitis

ACAAICOLA

Optimal control of asthma improved eosinophilic otitis media

Hypothesis & Experience  Open Access

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Asia Pac Allergy. 2018 Jan;8(1):e5. English. Published online Jan 24, 2018.  https://doi.org/10.5415/apallergy.2018.8.e5

Yukako Seo,1 Manabu Nonaka,1 Yukie Yamamura,1 Ruby Pawankar,2 and Etsuko Tagaya3

1Department of Otolaryngology, Tokyo Women’s Medical University, Tokyo 162-8666, Japan.

2Department of Pediatrics, Nippon Medical School, Tokyo 113-0022, Japan.

3First Department of Medicine, Tokyo Women’s Medical University, Tokyo 162-8666, Japan.

Correspondence to: Manabu Nonaka. Department of Otolaryngology, Tokyo Women’s Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. Tel: +81-3-3353-8111 (ext. 28531), Fax: +81-3-5269-7617, Email: nonaka-m@twmu.ac.jp

Abstract

Background Eosinophilic otitis media (EOM) is often associated with comorbid asthma. The middle ear cavity is part of the upper airway. Therefore, EOM and asthma can be considered to be a crucial part of the “one airway, one disease” phenomenon. Based on the concept of one airway, one disease in the context of allergic rhinitis and asthma, optimal level of inhalation therapy for better asthma control leads to improvement in allergic rhinitis.

Role of airway epithelial barrier dysfunction in pathogenesis of asthma

Allergology International

Volume 67, Issue 1, January 2018, Pages 12-17

Yasuhiro GonCorrespondence information about the author Yasuhiro GonEmail the author Yasuhiro Gon

,  Shu Hashimoto

Division of Respiratory Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan

Open Access

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Abstract

Bronchial asthma is characterized by persistent cough, increased sputum, and repeated wheezing. The pathophysiology underlying these symptoms is the hyper-responsiveness of the airway along with chronic airway inflammation. Repeated injury, repair, and regeneration of the airway epithelium following exposure to environmental factors and inflammation results in histological changes and functional abnormalities in the airway mucosal epithelium; such changes are believed to have a significant association with the pathophysiology of asthma. Damage to the barrier functions of the airway epithelium enhances mucosal permeability of foreign substances in the airway epithelium of patients with asthma. Thus, epithelial barrier fragility is closely involved in releasing epithelial cytokines (e.g., TSLP, IL-25, and IL-33) because of the activation of airway epithelial cells, dendritic cells, and innate group 2 innate lymphoid cells (ILC2). Functional abnormalities of the airway epithelial cells along with the activation of dendritic cells, Th2 cells, and ILC2 form a single immunopathological unit that is considered to cause allergic airway inflammation. Here we use the latest published literature to discuss the potential pathological mechanisms regarding the onset and progressive severity of asthma with regard to the disruption of the airway epithelial function.

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Profile of dupilumab and its potential in the treatment of inadequately controlled moderate-to-severe atopic dermatitis

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Authors Awosika O, Kim L, Mazhar M, Rengifo-Pardo M, Ehrlich A

Published 24 January 2018 Volume 2018:11 Pages 41—49

DOI https://doi.org/10.2147/CCID.S123329

Olabola Awosika,¹ Lori Kim,² Momina Mazhar,² Monica Rengifo-Pardo,^1,2 Alison Ehrlich<sup>1,2

1</sup>Department of Dermatology, The George Washington Medical Faculty Associates, Washington, DC, USA; ²George Washington University School of Medicine & Health Sciences, Washington, DC, USA

Abstract: Atopic dermatitis (AD) is a common inflammatory skin disorder that manifests as eczematous lesions, often associated with allergic rhinitis and asthma.