Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood

Edward Mitre, MD¹; Apryl Susi, MS²; Laura E. Kropp, MPH¹; et al

David J. Schwartz, MD³; Gregory H. Gorman, MD²; Cade M. Nylund, MD²

Author Affiliations Article Information

JAMA Pediatr. Published online April 2, 2018. doi:10.1001/jamapediatrics.2018.0315

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Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy And Allergic Diseases in Early Childhood

Key Points

Question  Does use of medications that disturb the microbiome in infancy increase subsequent risk of developing allergic diseases?

Findings  In this cohort study of 792 130 children, the hazard of developing an allergic disease was significantly increased in those who had received acid-suppressive medications or antibiotics during the first 6 months of life.

Meaning  Exposure to acid-suppressive medications or antibiotics in the first 6 months of life may increase risk of allergic disease development.

Critical view of anaphylaxis epidemiology: open questions and new perspectives

Allergy, Asthma & Clinical Immunology201814:12

https://doi.org/10.1186/s13223-018-0234-0

Luciana Kase TannoEmail author,

Ana Luiza Bierrenbach,

F. Estelle R. Simons,

Victoria Cardona,

Bernard Yu-Hor Thong,

Nicolas Molinari,

Moises A. Calderon,

Margitta Worm,

Yoon-Seok Chang,

Nikolaos G. Papadopoulos,

Thomas Casale,

Pascal Demoly and

on behalf the Joint Allergy Academies

AbstractIn contrast to the majority of allergic or hypersensitivity conditions, worldwide anaphylaxis epidemiological data remain sparse with low accuracy, which hampers comparable morbidity statistics. Data can differ widely depending on a number of variables.

Social Media as a Catalyst for Policy Action and Social Change for Health and Well-Being: Viewpoint

Journal of Medical Internet Research

• Douglas Yeung, PhD 

ABSTRACT

This viewpoint paper argues that policy interventions can benefit from the continued use of social media analytics, which can serve as an important complement to traditional social science data collection and analysis. Efforts to improve well-being should provide an opportunity to explore these areas more deeply, and encourage the efforts of those conducting national and local data collection on health to incorporate more of these emerging data sources.

Social media remains a relatively untapped source of information to catalyze policy action and social change. However, the diversity of social media platforms and available analysis techniques provides multiple ways to offer insight for policy making and decision making. For instance, social media content can provide timely information about the impact of policy interventions. Social media location information can inform where to deploy resources or disseminate public messaging. Network analysis of social media connections can reveal underserved populations who may be disconnected from public services. Machine learning can help recognize important patterns for disease surveillance or to model population sentiment. To fully realize these potential policy uses, limitations to social media data will need to be overcome, including data reliability and validity, and potential privacy risks.

Traditional data collection may not fully capture the upstream factors and systemic relationships that influence health and well-being. Policy actions and social change efforts, such as the Robert Wood Johnson Foundation’s effort to advance a culture of health, which are intended to drive change in a network of upstream health drivers, will need to incorporate a broad range of behavioral information, such as health attitudes or physical activity levels. Applying innovative techniques to emerging data has the potential to extract insight from unstructured data or fuse disparate sources of data, such as linking health attitudes that are expressed to health behaviors or broader health and well-being outcomes.

J Med Internet Res 2018;20(3):e94

doi:10.2196/jmir.8508

Why clinical trial outcomes fail to translate into benefits for patients

Commentary - Open Access - Open Peer Review

• TrialsEmail authorView ORCID ID profil
 

Carl HeneghanEmail authorView ORCID ID profile,

Ben Goldacre and

Kamal R. Mahtani

Trials201718:122https://doi.org/10.1186/s13063-017-1870-2

Open Peer Review reports

Abstract

Clinical research should ultimately improve patient care. For this to be possible, trials must evaluate outcomes that genuinely reflect real-world settings and concerns. However, many trials continue to measure and report outcomes that fall short of this clear requirement. We highlight problems with trial outcomes that make evidence difficult or impossible to interpret and that undermine the translation of research into practice and policy.

Bilastine safety in drivers who need antihistamines: new evidence from high-speed simulator driving test on allergic patients

Eur Rev Med Pharmacol Sci 2018; 22 (3): 820-828

DOI: 10.26355/eurrev_201802_14318

A. Demonte, M.B. Guanti, S. Liberati, A. Biffi, F. Fernando, M. Fainello, P. Pepe

Department of Surgical, Medical, Dental and Morphological Sciences with Interest in Transplant, Oncological and Regenerative Medicine; Dermatology Unit; University of Modena and Reggio Emilia, Modena, Italy. patrizia.pepe@unimore.it

• 
  

OBJECTIVE: Bilastine is a highly selective, non-sedating antihistamine, indicated for the symptomatic treatment of allergic rhinoconjunctivitis and urticaria. Available data suggest that bilastine interferes neither with driving ability nor with flying-related performance. However, no data are available on the effect of bilastine on the driving ability in extreme conditions. Here we analyzed the effect of 7 days treatment with 20 mg bilastine in patients with allergic rhinitis and/or chronic urticaria, on psychophysical performance assessed by the Formula One (F1) high-speed simulator-driving test.

The International Study of the Allergic Rhinitis Survey: outcomes from 4 geographical regions

Asia Pac Allergy. 2018 Jan;8(1):e7. English.  https://doi.org/10.5415/apallergy.2018.8.e7

Desiderio Passali,1 Cemal Cingi,2 Paola Staffa,1 Francesco Passali,3 Nuray Bayar Muluk,4and Maria Luisa Bellussi1

1Department of Otorhinolaryngology - Head and Neck Surgery, University of Siena, 53100 Siena, Italy.

2Department of Otorhinolaryngology - Head and Neck Surgery, Osmangazi University, Faculty of Medicine, 26040 Eskisehir, Turkey.

3ENT Clinic, University of Roma Tor Vergata, 00173 Rome, Italy.

4Department of Otorhinolaryngology - Head and Neck Surgery, Kırıkkale University, Faculty of Medicine, 71450 Kırıkkale, Turkey.

Abstract

Background Allergic rhinitis (AR) is a global health problem and is characterised by one or more symptoms, including sneezing, itching, nasal congestion and rhinorrhea.

Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis

PLOS MEDICINE

Vanessa Garcia-Larsen , Despo Ierodiakonou , Katharine Jarrold, Sergio Cunha, Jennifer Chivinge, Zoe Robinson, Natalie Geoghegan, Alisha Ruparelia, Pooja Devani, Marialena Trivella, Jo Leonardi-Bee, Robert J. Boyle 

https://doi.org/10.1371/journal.pmed.1002507

Abstract

Background

There is uncertainty about the influence of diet during pregnancy and infancy on a child’s immune development. We assessed whether variations in maternal or infant diet can influence risk of allergic or autoimmune disease.

Clinical implications of CD4+ T cell subsets in adult atopic asthma patients

• Allergy, Asthma & Clinical Immunology
• Research  Open Access

• Matthew Wiest†,
• Katherine Upchurch†,
• Wenjie Yin,
• Jerome Ellis,
• Yaming Xue,
• Bobby Lanier,
• Mark Millard,
• HyeMee Joo and
• SangKon OhEmail authorView ORCID ID profile

†Contributed equally

Allergy, Asthma & Clinical Immunology201814:7

https://doi.org/10.1186/s13223-018-0231-3

Abstract

Background T cells play a central role in chronic inflammation in asthma. However, the roles of individual subsets of T cells in the pathology of asthma in patients remain to be better understood.

Methods We investigated the potential signatures of T cell subset phenotypes in asthma using fresh whole blood from adult atopic asthma patients (n = 43) and non-asthmatic control subjects (n = 22). We further assessed their potential clinical implications by correlating asthma severity.