Pilot study: assessing the clinical diagnosis of allergy in atopic children using a microarray assay in addition to skin prick testing and serum specific IgE

RESEARCH

 

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• Ru-Xin FoongEmail author,
• Graham Roberts,
• Adam Tobias Fox and
• George du Toit

Clinical and Molecular Allergy201614:8

DOI: 10.1186/s12948-016-0046-z

Abstract

Background

Children with atopic dermatitis (AD) are at risk of developing allergy. Alongside clinical history, testing modalities include skin prick tests (SPT), specific immunoglobulin-E (sp-IgE) and recently, microarray assays. The aim of this pilot study was to assess current tests and the ISAC sIgE-112 system in the diagnosis of food and aeroallergen allergy.

Hypersensitivity and immunologic reactions to biologics: opportunities for the allergist

David A. Khan, MDPress enter key for correspondence informationPress enter key to Email the author

Department of Internal Medicine, Division of Allergy and Immunology, University of Texas Southwestern Medical Center, Dallas, Texas

DOI: http://dx.doi.org/10.1016/j.anai.2016.05.013

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Article Outline

1. Introduction
2. High Cytokine (Cytokine Release and Storm) Reactions
3. Common Acute Infusion Reactions
4. Hypersensitivity Reactions
5. Omalizumab
   1. Anaphylaxis to Omalizumab
   2. Proposed Mechanisms of Omalizumab Anaphylaxis
   3. Omalizumab Skin Testing
   4. Omalizumab Desensitization
   5. Omalizumab Serum Sickness-Like Reactions
6. Rituximab
   1. Immunodeficiency
   2. Serum Sickness-Like Reactions
   3. Anaphylaxis and Skin Testing
   4. Rapid Desensitization
7. Conclusions
8. References

Medical adherence to intranasal corticosteroids in adult patients

Brazilian Journal of Otorhinolaryngology

Available online 20 July 2016

In Press, Corrected Proof — Note to users

• Emre Ocak, 
• Baran Acar^, , 
• Deniz Kocaöz

doi:10.1016/j.bjorl.2016.06.007

Abstract

Introduction :The adherence to medical treatment in allergic rhinitis (AR) is poorly evaluated in clinical practice.

Objectives: To evaluate adherence to intranasal corticosteroids (ICS) in the treatment of allergic rhinitis AR patients.

Combination of specific allergen and probiotics induces specific regulatory B cells and enhances specific immunotherapy effect on allergic rhinitis

DOI: 10.18632/oncotarget.10946

Ling-Zhi Xu1,*, Li-Tao Yang1,2,*, Shu-Qi Qiu1,2,*, Gui Yang1,2, Xiang-Qian Luo3, Bei-Ping Miao4, Xiao-Rui Geng1,2, Zhi-Qiang Liu1,2, Jun Liu5, Zhong Wen6, Shuai Wang1,2, Huan-Ping Zhang7, Jing Li8, Zhi-Gang Liu1, Hua-Bin Li3 and Ping-Chang Yang1

DOI: 10.18632/oncotarget.10946

ABSTRACT

The therapeutic efficacy of allergen specific immunotherapy (SIT) on allergic diseases is to be improved. Probiotics can regulate immune response. This study aims to promote the effect of SIT on allergic rhinitis (AR) by co-administration with Clostridium butyricum(Cb). In this study, patients with AR sensitized to mite allergens were enrolled to this study, and treated with SIT or/and Cb. The therapeutic efficacy was evaluated by the total nasal symptom scores (NSS), medication scores, serum specific IgE levels and T helper (Th)2 cytokine levels. The improvement of immune regulation in the AR patients was assessed by immunologic approaches.

Defects of corneocyte structural proteins and epidermal barrier in atopic dermatitis

Volume 396, Issue 11 (Nov 2015)

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Marina Le Lamer1 / Laurence Pellerin1, a / Marie Reynier1 / Laura Cau1 / Valérie Pendaries1, b / Corinne Leprince1 / Marie-Claire Méchin1 / Guy Serre1 / Carle Paul1, 2 / Michel Simon3

Abstract

The main function of the epidermis is to establish a vital multifunctional barrier between the body and its external environment. A defective epidermal barrier is one of the key features of atopic dermatitis (AD), a chronic and relapsing inflammatory skin disorder that affects up to 20% of children and 2–3% of adults and often precedes the development of allergic rhinitis and asthma.

Behavioral interventions to reduce inappropriate antibiotic prescribing: a randomized pilot trial

RESEARCH ARTICLE

 

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OPEN PEER REVIEW

• Stephen D. PersellEmail author,
• Jason N. Doctor,
• Mark W. Friedberg,
• Daniella Meeker,
• Elisha Friesema,
• Andrew Cooper,
• Ajay Haryani,
• Dyanna L. Gregory,
• Craig R. Fox,
• Noah J. Goldstein and
• Jeffrey A. Linder

BMC Infectious DiseasesBMC series – open, inclusive and trusted201616:373

DOI: 10.1186/s12879-016-1715-8

©  The Author(s). 2016

Open Peer Review reports

Abstract

Background

Clinicians frequently prescribe antibiotics inappropriately for acute respiratory infections (ARIs). Our objective was to test information technology-enabled behavioral interventions to reduce inappropriate antibiotic prescribing for ARIs in a randomized controlled pilot test trial.

Climate Change and Air Pollution: Effects on Respiratory Allergy

Review
	Allergy Asthma Immunol Res. 2016 Sep;8(5):391-395.  Gennaro D'Amato,1,2 Ruby Pawankar,3 Carolina Vitale,4 Maurizia Lanza,4 Antonio Molino,4 Anna Stanziola,4 Alessandro Sanduzzi,2,5 Alessandro Vatrella,6 and Maria D'Amato4 1Division of Respiratory and Allergic Diseases, Department of Chest Diseases High Speciality, A. Cardarelli Hospital, Napoli, Italy. 2University "Federico II", Medical School, Naples, Italy. 3Division of Allergy, Department of Pediatrics, Nippon Medical School, Tokyo, Japan. 4First Division of Pneumology, High Speciality Hospital "V. Monaldi" and University "Federico II" Medical School, Naples, Italy. 5Second Division of Pneumology, High Speciality Hospital "V. Monaldi" and University "Federico II" Medical School, Naples, Italy. 6Department of Medicine and Surgery, University of Salerno, Salerno, Italy. Abstract A body of evidence suggests that major changes involving the atmosphere and the climate, including global warming induced by anthropogenic factors, have impact on the biosphere and human environment. Studies on the effects of climate change on respiratory allergy are still lacking and current knowledge is provided by epidemiological and experimental studies on the relationship between allergic respiratory diseases, asthma and environmental factors, such as meteorological variables, airborne allergens, and air pollution.

Identification of novel macrolides with antibacterial, anti-inflammatory and type I and III IFN-augmenting activity in airway epithelium

J. Antimicrob. Chemother. (2016)doi: 10.1093/jac/dkw222

James D. Porter1,2, 

Jennifer Watson1, 

Lee R. Roberts3, 

Simren K. Gill4, 

Helen Groves4,

Jaideep Dhariwal1,2, 

Mark H. Almond1,2, 

Ernie Wong1,2, 

Ross P. Walton1,2, 

Lyn H. Jones3, 

John Tregoning4, 

Iain Kilty3, 

Sebastian L. Johnston1,2 and 

Michael R. Edwards1,2,*

Author Affiliations

1. ¹Airway Disease Infection Section, National Heart Lung Institute, Imperial College London, London, UK
2. ²MRC & Asthma UK Centre for Allergic Mechanisms of Asthma, London, UK
3. ³Pfizer Inc., Cambridge, MA, USA
4. ⁴Mucosal Infection and Immunity Group, Section of Virology, Imperial College London, London, UK

 

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Abstract

Background Exacerbations of asthma and COPD are triggered by rhinoviruses. Uncontrolled inflammatory pathways, pathogenic bacterial burden and impaired antiviral immunity are thought to be important factors in disease severity and duration. Macrolides including azithromycin are often used to treat the above diseases, but exhibit variable levels of efficacy. Inhaled corticosteroids are also readily used in treatment, but may lack specificity. Ideally, new treatment alternatives should suppress unwanted inflammation, but spare beneficial antiviral immunity.