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Marina Le Lamer1 / Laurence Pellerin1, a / Marie Reynier1 / Laura Cau1 / Valérie Pendaries1, b / Corinne Leprince1 / Marie-Claire Méchin1 / Guy Serre1 / Carle Paul1, 2 / Michel Simon3
Abstract
The main function of the epidermis is to establish a vital multifunctional barrier between the body and its external environment. A defective epidermal barrier is one of the key features of atopic dermatitis (AD), a chronic and relapsing inflammatory skin disorder that affects up to 20% of children and 2–3% of adults and often precedes the development of allergic rhinitis and asthma.
This review summarizes recent discoveries on the origin of the skin barrier alterations in AD at the structural protein level, including hereditary and acquired components. The consequences of the epidermal barrier alteration on our current understanding of the pathogenesis of AD, and its possible implications on the treatment of patients, are discussed here.
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