Activation of coagulation, anti-coagulation, fibrinolysis and the complement system in patients with urticaria |
Abstract
Background: Recently released studies indicate that activation of blood coagulation may be involved in causing urticaria.
Objective: To evaluate whether or not anticoagulation, fibrinolysis and the complement system are also involved in the pathogenesis of urticaria.
Methods: Coagulant factors, anticoagulant factors, fibrinolytic markers and complement components were analysed in patients with acute urticaria (AU) and chronic urticaria (CU).
Conclusion: The activation of coagulation, anti-coagulation, fibrinolysis and the complement system may be involved in the pathogenesis of urticaria. It also indicates that coagulation conditions in CU patients can recover after antihistamine treatment, but do not immediately return to normal levels directly after administration.Results: Plasma levels of activated factor VII (FVIIa) were higher in AU patients (P <0 .01="" but="" cu="" different="" em="" in="" not="" patients="" significantly="">P0>
while levels of tissue-type plasminogen activator (t-PA) were decreased (P <0 .01="" c5a="" concentrations="" controls="" cu="" em="" healthy="" in="" of="" patients="" plasma="" superior="" those="" to="" were="">P 0>0>0>0><0 .01="" also="" c4="" em="" increased="" levels="" of="" serum="">P0> <0 .01="" strong="">0>
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