Genes and Autoimmunity - Intracellular Signaling and Microbiome Contribution. Open Access Book

Medicine » Immunology, Allergology and Rheumatology

Genes and Autoimmunity - Intracellular Signaling and Microbiome Contribution

Edited by Spaska Angelova Stanilova, ISBN 978-953-51-1028-6, Hard cover, 267 pages, Publisher: InTech, Chapters published March 13, 2013 under CC BY 3.0 license
DOI: 10.5772/45733

Autoimmune disorders are known to affect a substantial number of people worldwide, demonstrating a gender bias and are the second largest cause of chronic illness. Recently, the attention has been focused on lifestyle changes as a major factor in the rise of autoimmune disease frequency. The two sections of this book are focused on the new opportunities for moving research forward, leading to a new approach to prevention and treatment of autoimmune diseases. A better understanding of the mechanisms of gene expression and triggering signaling pathways, which is involved in autoimmune pathogenesis simultaneously with current data for the interaction of microbiota with human immune system, will help to better understand the immune imbalance implicated in autoimmunity.

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• Chapter 1  Genetic Susceptibility to Graves’ Ophthalmopathyby Junichi Tani and Yuji Hiromatsu
• Chapter 2  Gene Polymorphisms of Immunoregulatory Cytokines IL-10 and TGF-β1 in Systemic Lupus Erythematosusby Irena Manolova, Mariana Ivanova and Spaska Stanilova
• Chapter 3  Toll-Like Receptor 3 and Retinoic Acid-Inducible Gene-I Implicated to the Pathogenesis of Autoimmune Renal Diseasesby Hiroshi Tanaka and Tadaatsu Imaizumi
• Chapter 4  Gene Expression Pattern Characterises Development of Multiple Sclerosisby Lotti Tajouri, Ekua W. Brenu, Kevin Ashton, Donald R. Staines and Sonya M. Marshall-Gradisnik
• Chapter 5  Costimulatory Molecules in Rheumatic Diseases Revisited with an Emphasis on Their Roles in Autoimmune Sjögren’s Syndromeby Adrienne E. Gauna and Seunghee Cha
• Chapter 6  Immune Synapses Between Lymphocytes and Target Cells in Autoimmune Thyroid Diseasesby Iwona Ben-Skowronek and Roman Ciechanek
• Chapter 7  Microbiome and Autoimmunityby Natalie Cherepahina, Zaur Shogenov, Mariya Bocharova, Murat Agirov, Jamilyia Tabaksoeva, Mikhail Paltsev and Sergey Suchkov
• Chapter 8  Environmental Factors and Type 1 Diabetes Mellitus in Pediatric Age Groupby Giuseppe d'Annunzio, Andrea Accogli, Ramona Tallone, Sara Bolloli and Renata Lorini
• Chapter 9  Common Mechanisms of Pathogenesis of Tissue-Specific Autoimmune Diseases: The Edited Model to Illustrate Those for IDDM and Multiple Sclerosisby S. A. Krynskiy, A. V. Kostyakov, D. S. Kostyushev, D. A. Gnatenko and S. V. Suchkov
• Chapter 10  Chronic Fatigue Syndrome/Myalgic Encephalomyelitis and Parallels with Autoimmune Disordersby Ekua W. Brenu, Lotti Tajouri, Kevin J. Ashton, Donald R. Staines and Sonya M. Marshall-Gradisnik
• Chapter 11  Biomarkers of Inflammatory Arthritis and Proteomicsby Opeyemi S. Ademowo, Lisa Staunton, Oliver FitzGerald and Stephen R. Pennington