PLoS One. 2013; 8(5): e63858.
Published online 2013 May 16. doi: 10.1371/journal.pone.0063858
PMCID: PMC3655942
Association between Polymorphisms of the IL-23R Gene and Allergic Rhinitis in a Chinese Han Population
Sunil K. Ahuja, Editor
Abstract
Objective
Polymorphism of the interleukin-23 receptor gene corresponds with susceptibility to several immune-related diseases. For the terminal differentiation of IL-17-producing effector T-helper cells in vivo, the interleukin-23 receptor gene is of vital importance. As shown recently, Th17 cells probably have a great influence on the pathogenesis of allergic airway diseases. Our intention was to establish an association between polymorphisms in the IL-23R gene and allergic rhinitis (AR) in the Chinese Han population.
Methods
We included 358 AR patients and 407 control Chinese subjects in a case-control comparison. The study involved obtaining blood samples for DNA extraction genotyping and determination of 4 selected single-nucleotide polymorphisms in IL-23R by performing PCR restriction fragment length polymorphism analysis (PCR-RFLP).
Results
A substantially growing prevalence of the homozygous rs7517847 GG genotype and G allele appeared in the AR patients unlike that observed in the control individuals (P<0 .001="" addition="" against="" agtg="" and="" ar="" control="" frequencies="" ggca="" ggcg="" haplotype="" haplotypes="" high="" in="" individuals="" may="" observed="" of="" p="" patients="" protection="" provide="" results="" substantially="" suggest="" that="" the="" unlike="" were="">
Conclusions
To the best of our knowledge, this is the first study to demonstrate an important association between polymorphisms in IL-23R and AR in the Chinese Han population. A strong association between rs7517847 in a SNP of IL-23R, and AR was identified.
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