May 30, 2013

Successful treatment of mastocytic anaphylactic episodes with reduction of skin mast cells after anti-IgE therapy

Successful treatment of mastocytic anaphylactic episodes with reduction of skin mast cells after anti-IgE therapy

G. Paraskevopoulos, E. Sifnaios, K. Christodoulopoulos, et al.

Abstract


Mastocytosis is a clonal disease derived from hematopoietic bone marrow progenitor cells. Clinical manifestations of the disease vary greatly depending on tissue involvement. Omalizumab is a recombinant humanized monoclonal anti-IgE antibody licensed in the treatment of asthma with increasing reports of clinical efficiency in other allergic diseases. We describe a case of a patient with mastocytosis responsive clinically and patho-physiologically after anti-IgE treatment.

Keywords


Mastocytosis, omalizumab, mast cell, skin biopsy, treatment, anti-IgE
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