Review
Novel therapeutic agents in clinical development for systemic lupus erythematosus
Natasha Jordan, Pamela MK Lutalo and David P D’Cruz*
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BMC Medicine 2013, 11:120 doi:10.1186/1741-7015-11-120
Published: 3 May 2013
Abstract
Conventional immunosuppressive therapies have radically transformed patient survival in systemic lupus erythematosus (SLE), but their use is associated with considerable toxicity and a substantial proportion of patients remain refractory to treatment. A more comprehensive understanding of the complexity of SLE immunopathogenesis has evolved over the past decade and has led to the testing of several biologic agents in clinical trials. There is a clear need for new therapeutic agents that overcome these issues, and biologic agents offer exciting prospects as future SLE therapies.
An array of promising new therapies are currently emerging or are under development including B-cell depletion therapies, agents targeting B-cell survival factors, blockade of T-cell co-stimulation and anti-cytokine therapies, such as monoclonal antibodies against interleukin-6 and interferon-α.
Keywords:
Lupus nephritis; B-cell depletion; BLys; T-cell co-stimulation; Interferon-α, SLE
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