• Can Fam Physician
• v.59(7); Jul 2013
• PMC3710039

Can Fam Physician. 2013 July; 59(7): 745-746.

PMCID: PMC3710039

Anaphylaxislike cholinergic urticaria

Darío Antolín-Amérigo, MD

Physician in the Allergy Division at the Hospital Universitario Ramón y Cajal in Madrid, Spain.

Petruta Cristina Vlaicu, MD

Physician in the Allergy Division at the Hospital Universitario Ramón y Cajal in Madrid, Spain.

Belén De La Hoz Caballer, MD PhD

Physician in the Allergy Division at the Hospital Universitario Ramón y Cajal in Madrid, Spain.

Moisés Sánchez Cano, MD PhD

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Cholinergic urticaria (CU) can be defined as itching and whealing associated with exercise, hot showers, sweating, anxiety, or any other condition that increases the body’s core temperature. Cholinergic urticaria might present in a local or generalized form. The latter is characterized by the abrupt appearance of small wheals surrounded by a pronounced erythematous flare reaction beginning over the upper thorax and neck and subsequently spanning practically the entire body. Exercise-induced anaphylaxis should be ruled out.

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