Gastrin-Releasing Peptide-Expressing Nerves Comprise Subsets of Human Cutaneous Aδ and C Fibers that May Sense Pruritus

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Letter to the Editor

Journal of Investigative Dermatology advance online publication 11 July 2013; doi: 10.1038/jid.2013.194

Gastrin-Releasing Peptide-Expressing Nerves Comprise Subsets of Human Cutaneous Aδ and C Fibers that May Sense Pruritus
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Theresa R Timmes^1,2, Robert Rothbaum^1,2,  Kirti¹, Claudine Y Silva¹, Jag Bhawan¹, Deborah L Cummins¹ and Deon Wolpowitz¹

¹Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts, USA

Correspondence: Deon Wolpowitz, E-mail: dewolpow@bu.edu

²These authors contributed equally to this work.

Abbreviations: 

CGRP, calcitonin gene–related peptide; DEJ, dermoepidermal junction; GRP, gastrin-releasing peptide; GRPR, gastrin-releasing peptide receptor; IENF, intraepidermal nerve fibre; NF200, neurofilament 200; PGP9.5, protein gene product 9.5; SP, substance P; TRPV1, transient receptor potential vanilloid 1

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