REVIEW ARTICLE
Front. Immunol., 15 July 2013 | doi: 10.3389/fimmu.2013.00182
IL-1 and T helper immune responses
- Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy
CD4 T cells play a critical role in mediating adaptive immunity to a variety of pathogens as well as in tumor immunity. If not adequately regulated, CD4 T cells can be also involved in autoimmunity, asthma, and allergic responses. During TCR activation in a particular cytokine milieu, naïve CD4 T cells may differentiate into one of several lineages of T helper (Th) cells, including Th1, Th2, and Th17, as defined by their pattern of cytokine production and function. IL-1, the prototypic proinflammatory cytokine, has been shown to influence growth and differentiation of immunocompetent lymphocytes. The differential expression of IL-1RI on human CD4 T cell subsets confers distinct capacities to acquire specific effector functions. In this review, we summarize the role of IL-1 on CD4 T cells, in terms of differentiation, activation, and maintenance or survival.
Keywords: Th17 cells, Th2 cells, Th1 non-classic, IL-1RI and T cells, IL-1 and T cells
Citation: Santarlasci V, Cosmi L, Maggi L, Liotta F and Annunziato F (2013) IL-1 and T helper immune responses. Front. Immunol. 4:182. doi: 10.3389/fimmu.2013.00182
Received: 09 April 2013; Paper pending published: 12 May 2013;
Accepted: 24 June 2013; Published online: 15 July 2013.
Accepted: 24 June 2013; Published online: 15 July 2013.
Edited by:
Alberto Mantovani, University of Milan, Italy
Reviewed by:
Massimo Gadina, National Institutes of Health, USAHideki Ogura, Osaka University, Japan
Copyright: © 2013 Santarlasci, Cosmi, Maggi, Liotta and Annunziato. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
*Correspondence: Francesco Annunziato, Department of Experimental and Clinical Medicine, University of Florence, V.le Pieraccini 6, Florence 50134, Italy e-mail: f.annunziato@dmi.unifi.it, francesco.annunziato@unifi.it
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