From the *Department of Pediatrics, Division of Infectious Diseases, Turku University Hospital; †Department of Virology, University of Turku, Turku, Finland; and ‡Division of Infectious Diseases, Nationwide Children’s Hospital and Ohio State University, Columbus, OH.
The authors have no funding or conflicts of interest to disclose.
Address for correspondence: Olli Ruuskanen, MD, PhD, Department of Pediatrics, Turku, University Hospital, 20520 Turku, Finland. E-mail: olli.ruuskanen@tyks.fi.
Many large studies performed in 1960s detected human rhinovirus (HRV) by virus isolation in one quarter of the cases with acute upper respiratory infections, and HRV was mainly considered a common cold virus. Virus culture, the standard method for detection, was carried out in research laboratories with special expertise and the role of HRV outside common cold remained unclear. During 1990s, polymerase chain reaction (PCR) techniques for HRV became generally available and they revolutionized HRV studies bringing important new biologic and clinical observations.1–3
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