• J Thorac Dis
• v.5(3); Jun 2013
• PMC3698267

J Thorac Dis. 2013 June; 5(3): 298–301.

doi:  10.3978/j.issn.2072-1439.2013.02.01

PMCID: PMC3698267

Responsiveness to leukotriene D4 and methacholine for predicting efficacy of montelukast in asthma

Wei-Jie Guan,1 Jin-Ping Zheng,1 Yi Gao,1 Cai-Yu Jiang,2 Yan-Qing Xie,1 Xu Shi,1 Zheng Zhu,1 Jia-Ying An,1 Xin-Xin Yu,1 Wen-Ting Liu,1 and Nan-Shan Zhong1

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Abstract

A lower responsiveness to leukotriene D4 (LTD4) or higher LTD4/[methacholine (MCh)] potency ratio might suggest preferable outcomes of short-term montelukast monotherapy in terms of airway inflammation and lung function in asthmatic patients.

KEY WORDS : Asthma, leukotriene D4 (LTD4), leukotriene-responsive, leukotriene-unresponsive, methacholine (MCh), montelukast

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