MINI REVIEW ARTICLE
Front. Immunol., 12 August 2013 | doi: 10.3389/fimmu.2013.00227
Antigen and transforming growth factor beta receptors contribute to long term functional and phenotypic heterogeneity of memory CD8 T cells
- University of Connecticut Health Center, Farmington, CT, USA
Pathogen-specific CD8 T cells provide a mechanism for selectively eliminating host cells that are harboring intracellular pathogens. The pathogens are killed when lytic molecules are injected into the cytoplasm of the infected cells and begin an apoptotic cascade. Activated CD8 T cells also release large quantities of pro-inflammatory cytokines that stimulate other immune cells in the local vicinity. As the alveoli are extraordinarily sensitive to cytokine induced damage, multiple layers of immune regulation limit the activities of immune cells that enter the lungs. These mechanisms include receptor-mediated signaling pathways in CD8 T cells that respond to peptide antigens and transforming growth factor β. Both pathways influence the functional and phenotypic properties of long-lived CD8 T cells populations in peripheral and lymphoid tissues.
Keywords: transforming growth factor beta, CD8 T cells, homing receptors, prolonged antigen presentation, tissue-resident memory cells, migration
Citation: Hu Y and Cauley L (2013) Antigen and transforming growth factor beta receptors contribute to long term functional and phenotypic heterogeneity of memory CD8 T cells.Front. Immunol. 4:227. doi: 10.3389/fimmu.2013.00227
Received: 07 April 2013; Accepted: 18 July 2013;
Published online: 12 August 2013.
Published online: 12 August 2013.
Edited by:
Susan Swain, University of Massachusetts Medical School, USA
Reviewed by:
David Hildeman, Cincinnati Children’s Hospital, USAShahram Salek-Ardakani, University of Florida, USA
Copyright: © 2013 Hu and Cauley. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Linda Cauley, University of Connecticut Health Center, 263 Farmington Avenue, MC1319 Farmington, CT 06032, USA e-mail: lcauley@uchc.edu
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