Clinical Study
Autologous Serum Skin Test versus Autologous Plasma Skin Test in Patients with Chronic Spontaneous Urticaria
1Bulent Ecevit University, School of Medicine, Department of Dermatology, Kozlu, 67600 Zonguldak, Turkey
2Bulent Ecevit University, School of Medicine, Department of Immunology, Turkey
3Selcuk University, Selcuklu Medical Faculty, Department of Dermatology, Turkey
2Bulent Ecevit University, School of Medicine, Department of Immunology, Turkey
3Selcuk University, Selcuklu Medical Faculty, Department of Dermatology, Turkey
Received 7 April 2013; Accepted 19 June 2013
Academic Editor: Elizabeth Helen Kemp
Copyright © 2013 Aysegul Alpay et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Previous studies indicate that 25–45% of chronic urticaria patients have an autoimmune etiology. Autologous serum skin test (ASST) and autologous plasma skin test (APST) are simple tests for diagnosing chronic autoimmune urticaria (CAU). However, there are still some questions about the specificity of these tests. This study consisted of 50 patients with chronic spontaneous urticaria (CSU) and 50 sex- and age-matched healthy individuals aged 18 years, and older. A total of 31 (62%) patients and 5 (10%) control patients had positive ASST; 21 (42%) patients and 3 (6%) control patients had positive APST. Statistically significant differences were noted in ASST and APST positivity between the patient and control groups (ASST ; APST ). Thirteen (26%) patients and 5 (10%) control patients had antithyroglobulin antibodies or antithyroid peroxidase antibody positivity. No statistically significant differences were noted in thyroid autoantibodies between the patient and control groups (anti-TG ; anti-TPO ). We consider that the ASST and APST can both be used as in vivo tests for the assessment of autoimmunity in the etiology of CSU and that thyroid autoantibodies should be checked even when thyroid function tests reveal normal results in patients with CSU.
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