MINI REVIEW ARTICLE
Front. Immunol., 01 August 2013 | doi: 10.3389/fimmu.2013.00226
Dietary inhibitors of histone deacetylases in intestinal immunity and homeostasis
- Tytgat Institute for Liver and Intestinal Research, Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, Netherlands
Intestinal epithelial cells (IECs) are integral players in homeostasis of immunity and host defense in the gut and are under influence of the intestinal microbiome. Microbial metabolites and dietary components, including short chain fatty acids (acetate, propionate, and butyrate, SCFAs), have an impact on the physiology of IECs at multiple levels, including the inhibition of deacetylases affecting chromatin remodeling and global changes in transcriptional activity. The number and diversity of butyrate-producing bacteria is subject to factors related to age, disease, and to diet. At physiological levels, SCFAs are inhibitors of histone deacetylases (HDACs) which may explain the transcriptional effects of SCFAs on epithelial cells, although many effects of SCFAs on colonic mucosa can be ascribed to mechanisms beyond HDAC inhibition. Interference with this type of post-translational modification has great potential in cancer and different inflammatory diseases, because HDAC inhibition has anti-proliferative and anti-inflammatory effects in vitro, and in in vivo models of intestinal inflammation. Hence, the influence of dietary modulators on HDAC activity in epithelia is likely to be an important determinant of its responses to inflammatory and microbial challenges.
Keywords: HDAC, intestinal epithelium, inflammatory bowel diseases, short chain fatty acids, butyrate
Citation: Schilderink R, Verseijden C and de Jonge WJ (2013) Dietary inhibitors of histone deacetylases in intestinal immunity and homeostasis. Front. Immunol. 4:226. doi: 10.3389/fimmu.2013.00226
Received: 12 May 2013; Accepted: 18 July 2013;
Published online: 01 August 2013.
Published online: 01 August 2013.
Edited by:
Cecil Czerkinsky, Göteborg University, Sweden
Reviewed by:
Emma Slack, ETH Zürich, SwitzerlandJ. Rodrigo Mora, Massachusetts General Hospital, USA
Copyright: © 2013 Schilderink, Verseijden and de Jonge. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: W. J. de Jonge, Tytgat Institute for Liver and Intestinal Research, Academic Medical Center, Meibergdreef 69-71, 1105BK Amsterdam, Netherlands e-mail: w.j.dejonge@amc.uva.nl
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