- PLoS One
- v.8(2); 2013
- PMC3577847
PLoS One. 2013; 8(2): e56065.
Published online 2013 February 20. doi: 10.1371/journal.pone.0056065
PMCID: PMC3577847
Effects of Polymorphisms -1112C/T and +2044A/G in Interleukin-13 Gene on Asthma Risk: A Meta-Analysis
Simona Stager, Editor
This article has been cited by other articles in PMC.
Abstract
Background
Associations between interleukin-13 (IL-13) polymorphisms and asthma risk remained controversial and ambiguous. Therefore, we performed a meta-analysis to assess the associations between IL-13polymorphisms and asthma susceptibility.
Methods
Pubmed, EMBASE, Chinese National Knowledge Infrastructure (CNKI) and Wangfang databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to calculate the strength of association in the random-effects model.
Results
Thirty-four studies were included in this meta-analysis. The results indicated that IL13 -1112C/T polymorphism was significantly associated with asthma risk (OR
=1.20, 95% CI 1.08–1.34, P=0.0009) in a dominant genetic model. When stratifying for race, IL13 -1112C/T polymorphism exhibited increased asthma risk in Caucasians (OR=1.30, 95% CI 1.09–1.55, P=0.003), while no significant association was found in Asians and African Americans. In the subgroup analysis based on atopic status, significant association was observed in atopic patients (OR=1.25, 95% CI 1.07–1.45, P=0.004) but not in the non-atopic patients. In addition, a significant association between IL13+2044A/G polymorphism and asthma risk was observed (OR=1.18, 95% CI 1.08–1.28, P=0.0002). In the subgroup analysis by ethnicity, there were significant associations between IL13+2044A/G polymorphism and asthma risk in Asians (OR=1.19, 95% CI 1.04–1.36, P=0.01) and Caucasians (OR=1.22, 95% CI 1.06–1.40, P=0.005) but not in African Americans. In the subgroup analysis stratified by atopic status, a marginal significant association was found in atopic patients (OR=1.12, 95% CI 1.00–1.26, P=0.05).
=1.20, 95% CI 1.08–1.34, P=0.0009) in a dominant genetic model. When stratifying for race, IL13 -1112C/T polymorphism exhibited increased asthma risk in Caucasians (OR=1.30, 95% CI 1.09–1.55, P=0.003), while no significant association was found in Asians and African Americans. In the subgroup analysis based on atopic status, significant association was observed in atopic patients (OR=1.25, 95% CI 1.07–1.45, P=0.004) but not in the non-atopic patients. In addition, a significant association between IL13+2044A/G polymorphism and asthma risk was observed (OR=1.18, 95% CI 1.08–1.28, P=0.0002). In the subgroup analysis by ethnicity, there were significant associations between IL13+2044A/G polymorphism and asthma risk in Asians (OR=1.19, 95% CI 1.04–1.36, P=0.01) and Caucasians (OR=1.22, 95% CI 1.06–1.40, P=0.005) but not in African Americans. In the subgroup analysis stratified by atopic status, a marginal significant association was found in atopic patients (OR=1.12, 95% CI 1.00–1.26, P=0.05).Conclusions
This meta-analysis suggested that the IL13 -1112C/T and +2044A/G polymorphisms were risk factors for asthma.
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