ISRN Immunology
Volume 2013 (2013), Article ID 794962, 8 pages
http://dx.doi.org/10.1155/2013/794962
Research Article
Increased Frequency of Antigen-Specific Polyfunctional T Cells in Tuberculosis Patients
Department of Immunology, National Institute of Research in Tuberculosis (ICMR), Mayor V.R. Ramanathan Road, Chetput, Chennai, Tamil Nadu 600 031, India
Received 27 May 2013; Accepted 5 July 2013
Academic Editors: C. M. Artlett and A. Taylor-Robinson
Copyright © 2013 Basirudeen Syed Ahamed Kabeer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
This study assessed the polyfunctional T cells in healthy household contacts (HHCs) and TB patients. This study also assessed the memory subsets responsible for the secretion of IFN-γ during the short-term culture with Mycobacterium tuberculosis antigens. Frequencies of CD4+IFN-γ+TNF-α+ T cells and CD8+IFN-γ+TNF-α+ T cells specific to M. tuberculosis antigens were significantly higher in TB patients compared to HHC. IFN-γ-secreting T cells, during overnight stimulation with M. tuberculosis antigens, belonged to effector memory subset with a CD45RA−CD27− phenotype. However, the number of IFN-γ-secreting effector memory cells did not differ between HHC and TB patients.
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