- PLoS One
- v.8(9); 2013
- PMC3767795
PLoS One. 2013; 8(9): e73270.
Published online 2013 September 9. doi: 10.1371/journal.pone.0073270
PMCID: PMC3767795
Ryuichi Murakami,#1 Kaori Denda-Nagai,#1,* Shin-ichi Hashimoto,2 Shigenori Nagai,3 Masahira Hattori,2 and Tatsuro Irimura1,*¤
George Kassiotis, Editor
Abstract
Dendritic cell (DC) subsets in the skin and draining lymph nodes (LNs) are likely to elicit distinct immune response types. In skin and skin-draining LNs, a dermal DC subset expressing macrophage galactose-type C-type lectin 2 (MGL2/CD301b) was found distinct from migratory Langerhans cells (LCs) or CD103+ dermal DCs (dDCs). Lower expression levels of Th1-promoting and/or cross-presentation-related molecules were suggested by the transcriptome analysis and verified by the quantitative real-time PCR analysis in MGL2+ dDCs than in CD103+ dDCs. Transfer of MGL2+ dDCs but not CD103+ dDCs from FITC-sensitized mice induced a Th2-type immune response in vivo in a model of contact hypersensitivity. Targeting MGL2+ dDCs with a rat monoclonal antibody against MGL2 efficiently induced a humoral immune response with Th2-type properties, as determined by the antibody subclass. We propose that the properties of MGL2+ dDCs, are complementary to those of CD103+ dDCs and skew the immune response toward a Th2-type response.
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