Subcutaneous and Sublingual Immunotherapy To Treat Allergic Rhinitis/Rhinoconjunctivitis and Asthma

Comparative Effectiveness Review Summary Guides for Clinicians [Internet].

John M. Eisenberg Center for Clinical Decisions and Communications Science.

Baylor College of Medicine, Houston, Texas

Issued: August 22, 2013.

Research Focus for Clinicians

A systematic review was undertaken to summarize the evidence regarding the efficacy, comparative effectiveness, and safety of subcutaneous and sublingual immunotherapy for adult and pediatric patients. All included studies are randomized controlled trials (RCTs) and were published from January 1967 to May 2012. There are 74 RCTs on the efficacy and safety of subcutaneous immunotherapy (SCIT), 60 RCTs on the efficacy and safety of sublingual immunotherapy (SLIT), and 8 RCTs on head-to-head comparisons between both forms of immunotherapy. This summary is provided to assist clinicians in decisionmaking along with a patient’s values and preferences. Reviews of evidence should not be construed to represent clinical recommendations or guidelines. The HTML version of this clinician research summary provides links from findings in the Clinical Bottom Line and other tables to the full report for a more detailed discussion of the studies included in each analysis. The full report and the HTML version of this clinician research summary are available at www.effectivehealthcare.ahrq.gov/allergy-asthma-immunotherapy.cfm

Views

• Print View
• Cite this Page
• PDF version of this page (179K)

In this Page

• Research Focus for Clinicians
• Background
• Conclusions
• Clinical Bottom Line
• Gaps in Knowledge
• Ordering Information
• What To Discuss With Your Patients
• Resource for Patients
• Source