Volume 22 Issue 1 March 2013
 | Research Paper | |
Pages 44-50
Cindy MA de Bot1, *Heleen Moed1, Patrick JE Bindels1, Roy Gerth van Wijk2, Marjolein Y Berger1,3, Hans de Groot4, Johannes C de Jongste5,Johannes C van der Wouden1,6
1 Department of General Practice, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
2 Department of Allergology, Erasmus MC-University Medical Center, Rotterdam, The Netherlands
3 Department of General Practice, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
4 Department of Pediatric Allergology, Reinier de Graaf Groep, Delft, The Netherlands
5 Department of Pediatric Respiratory Medicine, Erasmus MC-University Medical Center/Sophia Children's Hospital, Rotterdam, The Netherlands
6 Department of General Practice and EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam, The Netherlands
Received 12 April 2012 • Accepted 19 October 2012 • Online 22 January 2013
Abstract
Background: Allergic rhinitis (AR) and asthma are both inflammatory diseases and are often associated. Relationships between fractional exhaled nitric oxide (FeNO) and asthma, atopy, and quality of life have been shown.
Aims: This study aimed to determine whether FeNO in children with AR (n=158) or combined AR and asthma (n=93) was associated with clinical symptoms, house dust mite (HDM)-specific IgE, and rhinitis-specific quality of life, both cross-sectionally and longitudinally.
Methods: Children with AR aged 6–18 years (n=251) in primary care were assessed for FeNO, nasal symptom scores, asthma symptom scores, quality of life, and HDM-specific IgE at baseline and 2 years later.
Results: We found similarly elevated FeNO in children with only AR and in those with combined AR and asthma. No correlations were found between FeNO and nasal or asthma symptoms and rhinitis-related quality of life. Longitudinal correlations were strongest for HDM-specific IgE (r=0.91, p-0.0001).
Conclusions: FeNO was similar in a selected group of children with AR with and without asthma in primary care and was unrelated to symptoms or quality of life in both groups. FeNO is unlikely to be a useful biomarker of the clinical severity of upper or lower airway disease in primary care.
Cite as: de Bot CMA, Moed H, Bindels PJE, van Wijk RG, Berger MY, de Groot H, de Jongste JC, van der Wouden JC. Exhaled nitric oxide measures allergy not symptoms in children with allergic rhinitis in primary care: a prospective cross-sectional and longitudinal cohort study.Prim Care Respir J 2013;22(1):44-50. DOI: http://dx.doi.org/10.4104/pcrj.2013.00009
Keywords
Fractional exhaled nitric oxide (FeNO), asthma, allergic rhinitis, child, quality of life
* Corresponding author. Heleen Moed Tel: +31-10-7031897 Fax: +31-10-7044766 Email:h.moed@erasmusmc.nl
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