Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 959650, 11 pages
http://dx.doi.org/10.1155/2013/959650
Research Article
1College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA
2College of Dental Medicine, Western University of Health Sciences, Pomona, CA 91766, USA
3Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA
2College of Dental Medicine, Western University of Health Sciences, Pomona, CA 91766, USA
3Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA 91766, USA
Received 28 August 2013; Accepted 1 October 2013
Academic Editor: Masha Fridkis-Hareli
Copyright © 2013 Devin Morris et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
We characterized the functions of neutrophils in response to Mycobacterium tuberculosis (M. tb) infection, with particular reference to glutathione (GSH). We examined the effects of GSH in improving the ability of neutrophils to control intracellular M. tb infection. Our findings indicate that increasing the intracellular levels of GSH with a liposomal formulation of GSH (L-GSH) resulted in reduction in the levels of free radicals and increased acidification of M. tb containing phagosomes leading to the inhibition in the growth of M. tb. This inhibitory mechanism is dependent on the presence of TNF-αand IL-6. Our studies demonstrate a novel regulatory mechanism adapted by the neutrophils to control M. tb infection.
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