Comparison of Specific IgE Antibodies to Wheat Component Allergens in Two Phenotypes of Wheat Allergy

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	Brief Communication  Open Access
	Young-Hee Nam,1 Eui-Kyung Hwang,2 Hyun Jung Jin,3 Jeong Min Lee,4 Yoo-Seob Shin,2 Young-Min Ye,2Arantxa Palacin,5 Gabriel Salcedo,5 Soo-Young Lee,4 and Hae-Sim Park2 1Department of Internal Medicine, Dong-A University School of Medicine, Busan, Korea. 2Department of Allergy & Clinical Immunology, Ajou University School of Medicine, Suwon, Korea. 3Department of Internal medicine, Yeungnam University College of Medicine, Daegu, Korea. 4Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea. 5Unidad de Bioquimica, Departamento de Biotecnología, E.T.S. Ingenieros Agronomos, Madrid, Spain. Address for Correspondence: Hae-Sim Park, MD. Department of Allergy & Clinical Immunology, Ajou University School of Medicine, 206 Worldcup-ro, Yeongtong-gu, Suwon 442-721, Korea. Tel: +82.31-219-5196, Fax: +82.31-219-5154, Email: hspark@ajou.ac.kr  Received June 14, 2013; Accepted August 19, 2013. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Specific IgE to gliadin was proposed as a marker for wheat dependent exercise induced anaphylaxis, while Tri a 14 was found to induce IgE response in baker's asthma. We evaluated whether these components could be used for discriminating phenotypes of wheat allergy. Twenty-nine patients who were wheat-induced anaphylaxis and/or urticaria (n=21, group I) and baker's asthma (n=8, group II) were enrolled. The prevalence of serum specific IgE to Tri a 14 was higher in group II (25%) than in group I (4.8%), while the serum specific IgE to gliadin was significantly higher in group I (70%) than in group II (12.5%). The cutoff value for predicting the baker's asthma using the ratio of serum specific IgE to Tri a 14 to gliadin was 742.8 optical density×1,000/(kU/L) with high sensitivity and specificity. These findings suggest that Tri a 14/gliadin may be a potential marker for predicting baker's asthma. Keywords: Baker's Asthma, Gliadin, Lipid Transfer Protein, Wheat. Formats: Article PubReader PDF Figures + Tables References Export: Download Citation E-mail Twitter Facebook Figures: