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Martín Bedolla-Barajas, 1 Dante D Hernández-Colín,1 Jaime Morales-Romero,2 and Carlos Serrano-Salinas3 |
| 1Allergy and Clinical Immunology Service, Division of Internal Medicine, Civil Hospital of Guadalajara "Dr. Juan I. Menchaca", Guadalajara, Jalisco 44340, Mexico. |
| 2Public Health Institute, University of Veracruz, Xalapa, Veracruz 91190, Mexico. |
| 3Internal Medicine Service, Division of Internal Medicine, Civil Hospital of Guadalajara "Dr. Juan I. Menchaca", Guadalajara, Jalisco 44340, Mexico. |
Correspondence: Martín Bedolla-Barajas. Allergy and Clinical Immunology Service, Division of Interrnal Medicine, Civil Hospital of Guadalajara "Dr. Juan I. Menchaca", Guadalajara, Jalisco 44650, México. Tel:+52-33-33-42-89-16, Fax:+52-33-33-42-89-16, Email: drmbedbar@gmail.com
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Received May 03, 2013; Accepted October 05, 2013.
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This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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Abstract
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Background
The pattern of the contrast media-induced adverse reactions has not been investigated extensively in Mexico.
Objective
To estimate the incidence and the degree of severity of the adverse reactions to contrast media, administered for the first time, in hospitalized subjects.
Methods
We studied 99 patients longitudinally on whom computed tomography with contrast media (iopamidol) was carried out. The adverse reactions were identified by clinical examination; subsequently, they were classified as mild, moderate and severe, following the Manual on Contrast Media version 9 guides, and as immediate and nonimmediate. In addition, the vital functions, oxygen saturation, serum creatinine levels and the total number of eosinophils were measured before and after the procedure.
Results
The incidence of immediate and nonimmediate adverse reactions was of 26.3% and 10.1%, respectively. The mild immediate reactions were 18 (69.2%), the most common being the sensation of warmth, nausea and pruritus; among the more delayed reactions, nephrotoxicity stood out (5.1%). The serum creatinine median showed no difference either before or after the intravenous injection of contrast media (p = 0.13); in contrast, there was a significant difference in the total number of eosinophils (p - 0.001). The values of high baseline systolic blood pressure and the diminished baseline amounts in pulse oximetry were significantly related with any type of the adverse reactions to contrast media.
Conclusion
The incidence of the adverse reactions to contrast media was greater with respect to previous reports; the majority of these reactions were of the immediate type and of a mild nature. The risk factors that have mostly been implicated in the adverse reactions to contrast media could not be identified in our cohort.
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Keywords: Contrast media, Incidence, Risk factors, Adverse drug reaction, X-ray computed tomography.
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Open Access
Article
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