Clinical and Developmental Immunology
Volume 2013 (2013), Article ID 464039, 9 pages
http://dx.doi.org/10.1155/2013/464039
Review Article
1Intensive Care Unit, 1st Department of Respiratory Medicine, Medical School, National and Kapodistrian University of Athens and “Sotiria” Chest Disease Hospital, 152 Mesogeion Avenue, 11527 Athens, Greece
23rd Department of Pulmonology, Sismanoglio General Hospital, 15126 Athens, Greece
31st Department of Respiratory Medicine, Medical School, National and Kapodistrian University of Athens and “Sotiria” Chest Disease Hospital, 11527 Athens, Greece
23rd Department of Pulmonology, Sismanoglio General Hospital, 15126 Athens, Greece
31st Department of Respiratory Medicine, Medical School, National and Kapodistrian University of Athens and “Sotiria” Chest Disease Hospital, 11527 Athens, Greece
Received 18 July 2013; Revised 8 October 2013; Accepted 11 October 2013
Academic Editor: Luca Gattinoni
Copyright © 2013 Nikoletta Rovina et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Detecting and treating active and latent tuberculosis are pivotal elements for effective infection control; yet, due to their significant inherent limitations, the diagnostic means for these two stages of tuberculosis (TB) to date remain suboptimal. This paper reviews the current diagnostic tools for mycobacterial infection and focuses on the application of flow cytometry as a promising method for rapid and reliable diagnosis of mycobacterial infection as well as discrimination between active and latent TB: it summarizes diagnostic biomarkers distinguishing the two states of infection and also features of the distinct immune response against Mycobacterium tuberculosis (Mtb) at certain stages of infection as revealed by flow cytometry to date.
No comments:
Post a Comment