- Biomed Res Int
- v.2013; 2013
- PMC3654634
Biomed Res Int. 2013; 2013: 905670.
Published online 2013 April 4. doi: 10.1155/2013/905670
PMCID: PMC3654634
Sesame Oil Attenuates Ovalbumin-Induced Pulmonary Edema and Bronchial Neutrophilic Inflammation in Mice
Dur-Zong Hsu, 1 Chuan-Teng Liu, 1 Pei-Yi Chu, 1 Ya-Hui Li, 1 Srinivasan Periasamy, 1 and Ming-Yie Liu 1 , 2 ,*
Abstract
Background. Allergic asthma is one of the most common chronic inflammatory diseases of airways. Severe asthma may lead to hospitalization and death. Sesame oil is a natural product with anti-inflammatory property. However, the effect of sesame oil on allergic asthma has never been studied.Objective. We investigate the effect of sesame oil on pulmonary inflammation in allergic asthma model.Methods. Allergic airway inflammation was induced by sensitizing with two doses of 10
mg ovalbumin (OVA) and then challenged with 1% OVA nebulizer exposure (1h/day) for 3 days. Sesame oil (0.25, 0.5, or 1mL/kg/day) was given orally 30min before each challenge. Samples were collected 24h after the last challenge. Results. Data showed that sesame oil inhibited pulmonary edema and decreased interleukin (IL)-1β and IL-6 levels in bronchoalveolar lavage fluid in OVA-treated mice. Sesame oil also decreased pulmonary nitrite level, inducible nitric oxide synthase expression, and neutrophil infiltration induced by OVA. Further, sesame oil decreased serum IgE level in OVA-treated mice. Conclusion. Sesame oil may attenuate pulmonary edema and bronchial neutrophilic inflammation by inhibiting systemic IgE level in allergic asthma.
mg ovalbumin (OVA) and then challenged with 1% OVA nebulizer exposure (1h/day) for 3 days. Sesame oil (0.25, 0.5, or 1mL/kg/day) was given orally 30min before each challenge. Samples were collected 24h after the last challenge. Results. Data showed that sesame oil inhibited pulmonary edema and decreased interleukin (IL)-1β and IL-6 levels in bronchoalveolar lavage fluid in OVA-treated mice. Sesame oil also decreased pulmonary nitrite level, inducible nitric oxide synthase expression, and neutrophil infiltration induced by OVA. Further, sesame oil decreased serum IgE level in OVA-treated mice. Conclusion. Sesame oil may attenuate pulmonary edema and bronchial neutrophilic inflammation by inhibiting systemic IgE level in allergic asthma.
Formats:
Abstract
Background. Allergic asthma is one of the most common chronic inflammatory diseases of airways. Severe asthma may lead to hospitalization and death. Sesame oil is a natural product with anti-inflammatory property. However, the effect of sesame oil on allergic asthma has never been studied.Objective. We investigate the effect of sesame oil on pulmonary inflammation in allergic asthma model.Methods. Allergic airway inflammation was induced by sensitizing with two doses of 10mg ovalbumin (OVA) and then challenged with 1% OVA nebulizer exposure (1h/day) for 3 days. Sesame oil (0.25, 0.5, or 1mL/kg/day) was given orally 30min before each challenge. Samples were collected 24h after the last challenge. Results. Data showed that sesame oil inhibited pulmonary edema and decreased interleukin (IL)-1β and IL-6 levels in bronchoalveolar lavage fluid in OVA-treated mice. Sesame oil also decreased pulmonary nitrite level, inducible nitric oxide synthase expression, and neutrophil infiltration induced by OVA. Further, sesame oil decreased serum IgE level in OVA-treated mice. Conclusion
mg ovalbumin (OVA) and then challenged with 1% OVA nebulizer exposure (1h/day) for 3 days. Sesame oil (0.25, 0.5, or 1mL/kg/day) was given orally 30min before each challenge. Samples were collected 24h after the last challenge. Results. Data showed that sesame oil inhibited pulmonary edema and decreased interleukin (IL)-1β and IL-6 levels in bronchoalveolar lavage fluid in OVA-treated mice. Sesame oil also decreased pulmonary nitrite level, inducible nitric oxide synthase expression, and neutrophil infiltration induced by OVA. Further, sesame oil decreased serum IgE level in OVA-treated mice. Conclusion
No comments:
Post a Comment