Brazilian Journal of Otorhinolaryngology
Print version ISSN 1808-8694
Braz. j. otorhinolaryngol. vol.79 no.5 São Paulo Sept./Oct. 2013
http://dx.doi.org/10.5935/1808-8694.20130110
ORIGINAL ARTICLES
Melissa Ameloti Gomes Avelino1, Isabela Jubé Wastowski2, Ricardo Gimenes Ferri3, Thaís Gomes Abrahão Elias4, Ana Paula Lindoso Lima4, Larissa Mesquita Nunes5, Shirley Shizue Nagata Pignatari6
1PhD; Adjunct Professor - Federal University of Goiás.
22 PhD; Professor - State University of Goiás
3MSc; Professor - Pontifical Catholic University of Goiás.
4Medical Student - Pontifical Catholic University of Goiás.
5Medical Student - Pontifical Catholic University of Goiás.
6MD; PhD; Professor - Federal University of São Paulo.
Sinonasal polyposis (SNP) is a chronic inflammatory pathology of the nasal/paranasal cavities which affects from 1%-4% of the population. Although polyps seem to be a manifestation of chronic inflammation of nasal/paranasal sinus mucosa in both allergic and non-allergic subjects, the pathogenesis of nasal polyposis remains unknown. Interleukin-17A (IL-17A) is a key inflammatory cytokine in many disorders. Little attention has been paid to the role of IL-17A in chronic inflammatory disorders.
OBJECTIVE:
To investigate the expression of IL-17A in the SNP and verify if this expression is a marker of good or bad prognosis.
METHOD:
Prospective study with 25 patients presenting with SNP were subjected to the immunohistochemistry technique. After a skin prick test, all patients were divided into atopic and nonatopic groups, and asthmatic or non-asthmatic.
RESULTS:
The IL-17A expression was observed in both atopic and nonatopic patients. The numbers of IL-17A positive cells were greater in nasal polyps of atopic patients than nonatopic (p = 0.0128).
CONCLUSION:
These results indicate that IL-17A may play an important role in the pathology of SNP. Considering the inflammatory properties of IL-17A, this study suggests that it could increase susceptibility to atopy and asthma.
Keywords: allergy and immunology; interleukin-17; nasal polyps
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