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Florin-Dan Popescu, Department of Allergology, “Carol Davila” University of Medicine and Pharmacy, “Nicolae Malaxa” Clinical Hospital, Department of Allergology and Clinical Immunology, 022441 Bucharest, Romania
Author contributions: Popescu FD solely contributed to the manuscript.
Correspondence to: Florin-Dan Popescu, MD, PhD, Associate Professor, Department of Allergology, “Carol Davila” University of Medicine and Pharmacy, “Nicolae Malaxa” Clinical Hospital, Department of Allergology and Clinical Immunology, 022441 Bucharest, Sector 2, Romania. florindanpopescu@ymail.com
Telephone: + 40-21-2555405 Fax: + 40-21-2555275
Received November 23, 2013; Revised January 5, 2014; Accepted February 16, 2014;
Abstract
Grass pollen allergy represents a significant cause of allergic morbidity worldwide. Component-resolved diagnosis biomarkers are increasingly used in allergy practice in order to evaluate the sensitization to grass pollen allergens, allowing the clinician to confirm genuine sensitization to the corresponding allergen plant sources and supporting an accurate prescription of allergy immunotherapy (AIT), an important approach in many regions of the world with great plant biodiversity and/or where pollen seasons may overlap. The search for candidate predictive biomarkers for grass pollen immunotherapy (tolerogenic dendritic cells and regulatory T cells biomarkers, serum blocking antibodies biomarkers, especially functional ones, immune activation and immune tolerance soluble biomarkers and apoptosis biomarkers) opens new opportunities for the early detection of clinical responders for AIT, for the follow-up of these patients and for the development of new allergy vaccines.
Keywords: Biomarkers, Molecular allergy, Grass pollen immunotherapy
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April 11, 2014
Molecular biomarkers for grass pollen immunotherapy
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