BioMed Research International
Volume 2014 (2014), Article ID 707634, 5 pages
http://dx.doi.org/10.1155/2014/707634
Clinical Study
1Clinical Department of Internal Disease, Dermatology and Allergology, Medical University of Silesia, M Sklodowskiej Curie 10, 41-800 Zabrze, Poland
2Outpatient Allergology Clinic, Lompy 16, 40-038 Katowice, Poland
2Outpatient Allergology Clinic, Lompy 16, 40-038 Katowice, Poland
Received 4 December 2013; Revised 18 February 2014; Accepted 24 February 2014; Published 24 March 2014
Academic Editor: Ralph Mösges
Copyright © 2014 Andrzej Bozek et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background. Specific immunotherapy (SIT) with an ultrarush administration schedule with Purethal for tree pollen allergens has been evaluated to assess its efficacy and safety. Methods. The study group consisted of 22 patients with symptoms of allergic rhinitis and confirmed allergy to tree pollens. Patients were randomized and given an administration schedule of either ultrarush therapy or conventional preseasonal SIT. Treatment was performed during three consecutive years. Results. After three years of treatment, a similar reduction in nasal symptoms was observed; according to the visual analog scale, there was a decrease from 3.991 ± 0.804 points to 1.634 ± 0.540 in the ultrarush group and from 3.845 ± 0.265 to 1.501 ± 0.418 in the group desensitized using the conventional method (). There was also a comparable reduction in the use of relief drugs during pollen season and an increase in the serum concentration of IgG4 to tree pollens. No significant differences in the safety profile were observed. Conclusion. An administration schedule of ultrarush SIT with Purethal Trees is a safe treatment in preliminary observations. This therapy is comparable with conventional administration of SIT in the field of efficacy and safety.
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