Allergen sensitization linked to climate and age, not to intermittent-persistent rhinitis in a cross-sectional cohort study in the (sub)tropics

Research

Désirée Larenas-Linnemann, Alexandra Michels, Hanna Dinger, Kijawasch Shah-Hosseini,Ralph Mösges, Alfredo Arias-Cruz, Marichuy Ambriz-Moreno, Martín Bedolla Barajas, Ruth Cerino Javier, María de la Luz Cid del Prado, Manuel Alejandro Moreno, Roberto García Almaráz, Cecilia Y García-Cobas, Daniel A Garcia Imperial, Rosa Garcia Muñoz, Dante Hernández-Colín, Francisco J Linares-Zapien, Jorge A Luna-Pech, Juan J Matta-Campos,Norma Martinez Jiménez, Miguel A Medina-Ávalos, Alejandra Medina Hernández, Alberto Monteverde Maldonado, Doris N López, Luis J Pizano Nazara, Emmanuel Ramirez Sanchez,Ramos López Domingo, Noel López Rodriguez-Pérez and Pablo G Rodriguez Ortiz

Author Affiliations

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Clinical and Translational Allergy 2014, 4:20  doi:10.1186/2045-7022-4-20

Published: 4 June 2014

Abstract (provisional)

Background

Allergen exposure leads to allergen sensitization in susceptible individuals and this might influence allergic rhinitis (AR) phenotype expression. We investigated whether sensitization patterns vary in a country with subtropical and tropical regions and if sensitization patterns relate to AR phenotypes or age.

Methods

In a national, cross-sectional study AR patients (2-70y) seen by allergists underwent blinded skin prick testing with a panel of 18 allergens and completed a validated questionnaire on AR phenotypes.

Results

628 patients were recruited. The major sensitizing allergen was house dust mite (HDM) (56%), followed by Bermuda grass (26%), ash (24%), oak (23%) and mesquite (21%) pollen, cat (22%) and cockroach (21%). Patients living in the tropical region were almost exclusively sensitized to HDM (87%). In the central agricultural zones sensitization is primarily to grass and tree pollen. Nationwide, most study subjects had perennial (82.2%), intermittent (56.5%) and moderate-severe (84.7%) AR. Sensitization was not related to the intermittent-persistent AR classification or to AR severity; seasonal AR was associated with tree (p - 0.05) and grass pollen sensitization (p - 0.01). HDM sensitization was more frequent in children (0-11y) and adolescents (12-17y) (subtropical region: p - 0.0005; tropical region p - 0.05), but pollen sensitization becomes more important in the adult patients visiting allergists (Adults vs children + adolescents for tree pollen: p - 0.0001, weeds: p - 0.0005).

Conclusions

In a country with (sub)tropical climate zones SPT sensitization patterns varied according to climatological zones; they were different from those found in Europe, HDM sensitization far outweighing pollen allergies and Bermuda grass and Ash pollen being the main grass and tree allergens, respectively. Pollen sensitization was related to SAR, but no relation between sensitization and intermittent-persistent AR or AR severity could be detected. Sensitization patterns vary with age (child HDM, adult pollen). Clinical implications of our findings are dual: only a few allergens -some region specific- cover the majority of sensitizations in (sub)tropical climate zones. This is of major importance for allergen manufacturers and immunotherapy planning. Secondly, patient selection in clinical trials should be based on the intermittent-persistent and severity classifications, rather than on the seasonal-perennial AR subtypes, especially when conducted in (sub)tropical countries.

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