| Departments of Dermatology and 1Clinical Laboratory, Yantai Yuhuangding Hospital of Qingdao University Medical College, 2Blood Center in Yantai, Yantai, China |
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| This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
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| Background: The etiology of chronic idiopathic urticaria (CIU) is not completely clear. There are a few antibodies were reported to correlate with CIU. Objective: To inve-stigate the correlation these antibodies and CIU. Methods: The autologous serum skin test (ASST) and allergens were performed. Serum levels of immunoglobulin E (IgE), anti- FcεRI and anti-IgE, anti-Helicobacter pylori (HP) antibodies and anti-thyroglobulin antibody (TGAb) were measured in 100 patients with CIU, acute urticaria (AU) and normal controls respectively. Results: Eighty-six percent food or inhalant allergens were detected in AU patients, but no allergens were detected in CIU patients and normal controls. Serum anti-FcεRI antibody and anti-IgE antibody levels were higher in the CIU than that in the AU patients and normal controls (p-0.05, respectively). IgE level was lower in the CIU patients (T=190.00, p-0.05), but increased in the AU patients (T=226.00, p-0.05) compared with the normal controls. The ASST positive rates in the CIU and the AU patients were 53.4% and 12.6% respectively, but all normal controls were negative. The anti-FcεRI antibody level was higher in the ASST-positive CIU patients than those negative ones (T=101.73, p-0.05). In anti-HP antibody positive and TGAb positive CIU patients, anti-FcεRI anti-body positive rate was higher than AU patients (p-0.01) and normal controls (p＜0.01). Conclusion: The anti-FcεRI and anti-IgE antibodies play a key role in CIU, but anti-HP antibody and TGAb have an indirect correlation with CIU. (Ann Dermatol 26(2) 145∼149, 2014) |
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| Keyword : Antibody, Anti-Helicobacter pylori antibody, Anti-immu-noglobulin E antibody, Chronic idiopathic urticaria, Anti- thyroglobulin |
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