| ORIGINAL ARTICLE | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Year : 2014 | Volume : 9 | Issue : 4 | Page : 216-220 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| Subramanian Natarajan1, Poonam Subramanian2 1 Department of Pulmonary Medicine, Dhanwantary Hospital, Mumbai, India 2 Department of Pulmonary Medicine, The Lung Centre, Mumbai, Maharashtra, India
Correspondence Address: Subramanian Natarajan Department of Pulmonary Medicine, Dhanwantary Hospital, Mulund West-400 080, Mumbai, Maharashtra India  DOI: 10.4103/1817-1737.140130 | ||||||||||||||||||||||||||||||||||||||||||||||||||
Background: Allergic Broncho Pulmonary Aspergillosis (ABPA) is a rare disease characterized by an allergic
inflammatory response to the colonization by aspergillus or other fungi in the airways. The aim was to study the
clinical, radiological, and serological characteristics of patients of ABPA.
Materials and Methods: A prospective observational study of patients with breathlessness, chronic cough,
blood eosinophilia, and infiltrates on chest X-ray were evaluated with serologic and allergic skin fungal tests
using 15 common fungal antigens. Total of 24 patients were diagnosed as ABPA.
Results: Total 24 patients, 15 males (62%), 9 females (38%). Age range: 14-70 years, mean 49.13, standard
deviation (SD) 14.12. Central bronchiectasis - sixteen patients, bronchocoele - one patient, consolidation - five
patients, collapse with mucous plugging with areas of consolidation - three patients, one patient had
bronchiectasis, consolidation with hemorrhagic pleural effusion. Fifty-eight percent of patients had received
anti-tuberculosis medications prior to diagnosis. Serum total IgE varied from 340 to 18100 IU/mL. Two patients
had IgE levels below 1,000 IU/mL. The mean decrease in Serum total IgE levels at the end of 1 month
was 26.1% (range: 0.7-71.9%) and at the end of 2 months was 58.9% (range: 11.11-93.26%) (P value of 0.004).
Two patients had skin sensitivity to fungal antigens other than aspergillus species.
Conclusion: ABPA is a disease with varied clinical, radiological, and serological patterns.
Serum IgE monitoring may be done at the end of 2 and 6 months. Further studies are required to simplify
the diagnosis and treatment algorithms in resource-limited countries.
Keywords: Allergic, aspergillosis, bronchopulmonary, radiological, serological
How to cite this article:
Natarajan S, Subramanian P. Allergic bronchopulmonary aspergillosis: A clinical review of 24 patients: Are we right
in frequent serologic monitoring?. Ann Thorac Med 2014;9:216-20
How to cite this URL:
Natarajan S, Subramanian P. Allergic bronchopulmonary aspergillosis: A clinical review of 24 patients: Are we right
in frequent serologic monitoring?. Ann Thorac Med [serial online] 2014 [cited 2014 Sep 21];9:216-20.
Available from: http://www.thoracicmedicine.org/text.asp?2014/9/4/216/140130
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