Efficacy and Safety of Inhaled and Intranasal Corticosteroids

Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

(Formerly Current Medicinal Chemistry - Anti-Inflammatory and Anti-Allergy Agents)

DOI: 10.2174/1871523013666140826115204

Author(s): Akefeh Ahmadiafshar and Sahar Ahmadiafshar

Abstract:

Inflammation is an important phenomenon in allergic disorders and corticosteroid drugs since their anti inflammatory properties have a pivotal role in improvement, control and relieving the symptoms and signs of asthma, allergic rhinitis, atopic dermatitis and many other inflammatory disorders.

Nevertheless, the prescription of these drugs might be associated with some unwanted reactions such as hyperglycemia, hypertension, Cushing's syndrome, adrenal insufficiency and growth failure. In recent decades administration of intranasal and inhaled corticosteroids instead of systemic parenteral or oral drugs reduced some of these concerns during treatment of patients and enable them to receive the effective and safer kind of therapy in acute or chronic inflammatory disorders of nose and airways. In this article the properties of inhaler (ICS) and intranasal corticosteroids (INCS) were reviewed.

Keywords:

Efficacy, inhaled corticosteroid (ICS), intranasal corticosteroid (INCS), side effects.

Affiliation:

Pediatric Ward, Metabolic Disease Research Center and Social Determinant of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran.