Won HK1, Lee JW1, Song WJ1, Klaewsongkram J2, Kang MG3, Park HK1, Lee HS1, Kim MH4, Chang YS3, Cho SH1, Min KU1.
Abstract
Lamotrigine is a recent medication which is prescribed for various neuropsychiatric conditions. It is generally well-tolerated, but recent pharmacoepidemiological evidence suggests that lamotrigine is associated with risks of developing severe cutaneous drug reactions like toxic epidermal necrolysis (TEN). However, there still remains the diagnostic challenge regarding how to confirm the drug causality in suspected cases. In most cases so far, lamotrigine causality has not been objectively demonstrated, which was possibly due to high risk of oral challenge tests or the lack of useful in vitro drug assays. Here we report a case of lamotrigine-induced TEN, of which the drug causality was confirmed by in vitro granulysin and cytokine assays.
KEYWORDS:
Cyclosporine; Granulysin; Lamotrigine; Natural killer cells; Toxic epidermal necrolysis
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