| Abstract
Leukotriene receptor antagonists, which are generally considered safe with a few
adverse drug reactions, are increasingly used in the treatment of various allergic
diseases, including asthma and allergic rhinitis. Although a few anaphylactic
reactions to montelukast have been reported worldwide, there is still a lack of
reports about severe adverse drug reactions associated with pranlukast. Here, we
report a case of severe hypersensitivity reaction associated with pranlukast.
A 65-year-old woman developed anaphylactic shock that presented as generalized
urticaria, angioedema, collapse, and loss of consciousness after receiving
pranlukast. A positive response to oral challenge and skin prick testing with
pranlukast was observed in the patient. In this case, it was demonstrated that
pranlukast can induce anaphylaxis, possibly mediated by the IgE-dependent
pathway.
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Open Access
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