Pediatric Allergy and Immunology
Abstract
Panallergens comprise various protein families of plant as well as animal origin and are responsible for wide IgE cross-reactivity between related and unrelated allergenic sources.
Such cross-reactivities include reactions between various pollen sources, pollen and plant-derived foods as well as invertebrate-derived inhalants and foodstuff. Here we provide an overview on the most clinically relevant panallergens from plants (profilins, polcalcins, non-specific lipid transfer proteins, pathogenesis-related protein family 10 members) and on the prominent animal-derived panallergen family, topomyosins. In addition, we explore the role of panallergens in the sensitisation process and progress of the allergic disease. Emphasis is given on epidemiological aspects of panallergen sensitisation and clinical manifestations. Finally, the issues related to diagnosis and therapy of patients sensitised to panallergens is outlined and the use of panallergens as predictors for cross-reactive allergy and as biomarkers for disease severity is discussed
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