Multisystem reactions during egg oral food challenges may be associated with less severe reactions on initial presentation

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• Girish Vitalpur†Email author,
• Ann Esquivel†,
• Kirsten M. Kloepfer,
• James E. Slaven and
• Frederick E. Leickly

†Contributed equally

Allergy, Asthma & Clinical Immunology201612:21

DOI: 10.1186/s13223-016-0125-1

Abstract

In this study, we assessed whether multisystem reactions to egg and extensively-heated (EH) egg during OFCs were associated with a history of multisystem reactions. Records of children, who underwent OFC to egg or EH egg over a five-year period were reviewed.

Of the 120 challenges, 26 (21.67 %) failed, with 38.4 % (10/26) having multisystem reactions. Of the 13 who had multisystem reactions on initial presentation, only two (15.4 %) had a similar OFC outcome. Eighty percent (8/10) of those who had a multisystem OFC reaction had a less severe initial presentation. Initial and OFC multisystem reactions were not associated with each other.

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