Molecular Aspects of Allergen-Specific Immunotherapy in Patients with Seasonal Allergic Rhinitis

Open AccessSystematic Review

by 

Marina Izmailovich

 1,*,

Yuliya Semenova

 2,

Gulzada Abdushukurova

 3,

Ainur Mukhamejanova

 4,

Azhar Dyussupova

 5,

Raida Faizova

 5,

Meruert Gazaliyeva

 6,

Leila Akhvlediani

 7,

Natalya Glushkova

 8,

Sundetgali Kalmakhanov

 9 and

Geir Bjørklund

 10

Cells 2023, 12(3), 383; https://doi.org/10.3390/cells12030383

Abstract

A systematic review and narrative synthesis of publications was undertaken to analyze the role of component-resolved diagnosis technology in identifying polysensitization for the provision of allergen-specific immunotherapy to patients with seasonal allergic rhinitis. A search of publications was carried out in electronic databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The search helped to identify 568 publications, 12 of which were included in this review. Overall, 3302 patients were enrolled. The major finding was that component-resolved diagnostics change the choice of relevant allergens for allergen-specific immunotherapy in at least 50% of cases. Sensitization to allergen components differs with age, type of disease, and overall disease duration. Patients who had both bronchial asthma and allergic rhinitis were sensitized to a larger number of allergens than patients who had bronchial asthma alone.

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