Eosinophil-independent IL-5 levels are increased in critically ill COVID-19 patients who survive

• Letter to the editor
• Open Access
• 
  

• Xiaotian Ju, 
• Kiho Son, 
• Rameen Jamil, 
• Sarah Culgin, 
• Brittany Salter, 
• Kate Miyasaki, 
• Nahal Emami Fard, 
• Maria Xiao, 
• Zil Patel, 
• Kayla Zhang, 
• Braeden Cowbrough, 
• Melanie Kjarsgaard, 
• Katherine Radford, 
• Anna Dvorkin-Gheva, 
• Carl D. Richards, 
• Gerard Cox, 
• Zain Chagla, 
• Marek Smieja, 
• Marcel Tunks, 
• Waleed Alhazzani, 
• Dawn M.E. Bowdish, 
• Dan Perri, 
• Parameswaran K. Nair, 
• Roma Sehmi & 
• Manali Mukherjee 

Allergy, Asthma & Clinical Immunology volume 19, Article number: 58 (2023)

• details

Dear Editor,

Eosinopenia is predictive of disease severity in COVID-19, and baseline eosinophilia (in asthmatics or non-asthmatics) is associated with a lower risk of severe COVID-19 infection, usually with favourable outcomes.

Differential cell counts and cytokine levels
in blood and endotracheal aspirates in
intubated patients with severe COVID-19.

It remains unclear whether eosinophils are directly responsible for this outcome or if they are a biomarker of a Type 2 (T2) response that skews the T1 hyperinflammatory response. This study investigated the airway cellular source of T2 cytokines and levels changes with worsening of COVID-19 in intubated patients...

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