Levels of nasal nitric oxide and nitric oxide synthase expression in chronic rhinosinusitis with nasal polyposis

Wu V, Cusimano M, Marsden P, Lee JM. Int Forum Allergy Rhinol. 2023 Jul 3. doi: 10.1002/alr.23233. Epub ahead of print.

Abstract

KEY POINTS

• CRSwNP patients had decreased nNO and increased SNOT-22, endoscopy, and CT scores.
• CRSwNP patients exhibited decreased nNO despite elevated iNOS and eNOS mRNA expression.
• The mechanism behind lowered nNO in CRSwNP may not be related to NOS expression.

1 INTRODUCTION

Nitric oxide (NO) has been shown to be produced constitutively by the mucosa of the paranasal sinuses via the actions of inducible NO synthase (iNOS) and endothelial NO synthase (eNOS).1, 2 Physiologically, high levels of nasal NO (nNO) have been hypothesized to be important in maintaining sinus health.3-5 Lowered nNO levels have been linked to impaired mucociliary function and diminished host defense, and are characteristic of inflammatory diseases such as chronic rhinosinusitis with nasal polyposis (CRSwNP). Our objective was to determine the correlation between levels of nNO with iNOS and eNOS mRNA expression in CRSwNP patients compared to non-CRSwNP controls...

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