Idiopathic Hypereosinophilic Syndrome Presenting as Eosinophilic Hepatitis

Drake Seccurro, Debra W. Yen, Yashu Dhamija, et al. AIM Clinical Cases.2024;3:e240539. [Epub 19 November 2024]. doi:10.7326/aimcc.2024.0539

Abstract

Idiopathic hypereosinophilic syndrome (IHES) is defined by peripheral eosinophilia of more than 1500 eosinophils/µL for a 6-month duration with signs of organ involvement in the absence of parasitic infection, allergic reaction, or other recognized causes of eosinophilia. 

Portal inflammation with eosinophilic infiltration.

It is known to affect multiple organs with activated eosinophils that may lead to organ failure. Thirty percent of patients have liver involvement described as hepatomegaly and mildly elevated liver enzymes. We describe a rare case in which IHES was diagnosed after our patient presented with isolated acute hepatitis and was found to have peripheral eosinophilia and prominent eosinophils on liver biopsy.

PDF