Mast cells and basophils in cutaneous immune responses

Atsushi Otsuka and Kenji Kabashima

Allergy (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

Abstract

Mast cells and basophils share some functions in common and are generally associated with T helper 2 (Th2) immune responses, but taking basophils as surrogate cells for mast cell research or vice versa for several decades is problematic. Thus far, their in vitro functions have been well studied, but their in vivo functions remained poorly understood.

Elucidation of pathways driving asthma pathogenesis: development of a systems-level analytic strategy

Front. Immunol., 23 September 2014 | doi: 10.3389/fimmu.2014.00447

Michael L. Walker¹, Kathryn E. Holt^2,3, Gary P. Anderson⁴, Shu Mei Teo^1,2, Peter D. Sly⁵, Patrick G. Holt^3,5* and Michael Inouye^1,3,6

• 1Medical Systems Biology, Department of Pathology, The University of Melbourne, Parkville, VIC, Australia
• 2Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Melbourne, VIC, Australia
• 3Telethon Kids Institute, The University of Western Australia, West Perth, WA, Australia
• 4Department of Pharmacology and Therapeutics, Lung Health Research Centre, The University of Melbourne, Melbourne, VIC, Australia
• 5Queensland Children’s Medical Research Institute, The University of Queensland, Brisbane, QLD, Australia
• 6Medical Systems Biology, Department of Microbiology and Immunology, The University of Melbourne, Parkville, VIC, Australia

Asthma is a genetically complex, chronic lung disease defined clinically as episodic airflow limitation and breathlessness that is at least partially reversible, either spontaneously or in response to therapy.

Changes in Allergen Sensitization Over The Last 30 Years in Korea Respiratory Allergic Patients: A Single-Center

Allergy Asthma Immunol Res. 2014 Sep;6(5):434-443. English. Published online Jul 09, 2014.  http://dx.doi.org/10.4168/aair.2014.6.5.434

Copyright © 2014 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease

Hye Jung Park,1,2 Hyun Sun Lim,3 Kyung Hee Park,1,2 Jae-Hyun Lee,1,2 Jung-Won Park,1,2 and Chein-Soo Hong1,2

1Division of Allergy and Immunology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.

2Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.

3Biomedical Research Center, Yonsei University College of Medicine, Seoul, Korea.

Work-related airway symptoms, nasal reactivity and health-related quality of life in female hairdressers: a follow-up study during exposure

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Abstract

Objectives

Hairdressers often complain of work-related rhinitis (WR). They are infrequently sensitized to persulphates. The cause and mechanism of the symptoms and the effects on their health-related quality of life (HRQoL) remains unclear. The objectives were to follow female hairdressers with WR mainly from bleaching powder regarding nasal reactivity to persulphate and to evaluate symptoms, HRQoL and inflammatory markers in nasal lavage during a working period after vacation and compared with hairdressers without symptoms and pollen allergic women.

Methods

Skin prick tests to persulphate were performed in the hairdressers. Participants kept a diary of symptoms and of work tasks (hairdressers only). They completed HRQoL questionnaires. Eosinophil cationic protein (ECP) in nasal lavage fluid was examined. The symptomatic hairdressers performed nasal challenges with persulphate before and after the exposure.

Results

Skin prick tests were negative. Although the nasal reactivity to persulphate did not change a steady increase in nasal symptoms, especially blockage, and in ECP was noticed in the symptomatic hairdressers. The HRQoL deteriorated in the symptomatic hairdressers indicating an effect on their working situation and daily life. The atopics had more, but varying symptoms (itching, sneezing and secretion).

Conclusions

The difference in the clinical picture between the symptomatic hairdressers and the pollen allergic women, the increase in symptoms and ECP in the nasal lavage support the view that a sensitization to hairdresser chemicals by a mechanism not yet understood is operating. The deterioration of the HRQoL in the symptomatic hairdressers indicates a considerable effect on their life.

Keywords: 

Int Arch Occup Environ Health. 2014; 87(1): 61–71.

Published online Dec 23, 2012. doi:  10.1007/s00420-012-0835-8

PMCID: PMC3880473

K. Kronholm Diab, B. A. G. Jönsson, A. Axmon, and J. Nielsen

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Vitamin D-binding protein controls T cell responses to vitamin D

Research article

Martin Kongsbak¹, Marina Rode von Essen¹, Trine Bøegh Levring¹, Peter Schjerling²³,Anders Woetmann¹, Niels Ødum¹, Charlotte Menné Bonefeld¹ and Carsten Geisler^1*

• *Corresponding author: Carsten Geisler cge@sund.ku.dk

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BMC Immunology 2014, 15:35  doi:10.1186/s12865-014-0035-2

Published: 18 September 2014

Non specific pattern of lung function in a respiratory physiology unit: causes and prevalence: results of an observational cross-sectional and longitudinal study

Research article

Brigitte Chevalier-Bidaud, Karine Gillet-Juvin, Etienne Callens, Romain Chenu, Sémia Graba, Mohamed Essalhi and Christophe Delclaux

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BMC Pulmonary Medicine 2014, 14:148  doi:10.1186/1471-2466-14-148

Published: 19 September 2014

Allergic bronchopulmonary aspergillosis: A clinical review of 24 patients: Are we right in frequent serologic monitoring?

ORIGINAL ARTICLE

Year : 2014  |  Volume : 9  |  Issue : 4  |  Page : 216-220

Subramanian Natarajan1, Poonam Subramanian2 1 Department of Pulmonary Medicine, Dhanwantary Hospital, Mumbai, India 2 Department of Pulmonary Medicine, The Lung Centre, Mumbai, Maharashtra, India

Modulation of distinct asthmatic phenotypes in mice by dose-dependent inhalation of microbial products

Environ Health Perspect; DOI:10.1289/ehp.1307280

Gregory S. Whitehead, Seddon Y. Thomas, and Donald N. Cook

Differences in the intrinsic immunogenicity and allergenicity of Bet v 1 and related food allergens revealed by site-directed mutagenesis

Original Article

You have full text access to this OnlineOpen article

1. A. Roulias¹, 
2. U. Pichler², 
3. M. Hauser², 
4. M. Himly¹, 
5. H. Hofer¹, 
6. P. Lackner¹, 
7. C. Ebner³,
8. P. Briza¹, 
9. B. Bohle⁴, 
10. M. Egger², 
11. M. Wallner² and
12. F. Ferreira^2,*
Article first published online: 14 NOV 2013 
DOI: 10.1111/all.12306  Allergy Volume 69, Issue 2, pages 208–215, February 2014
© 2013 The Authors. Allergy published by John Wiley & Sons Ltd
This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Bioequivalence of two formulations of montelukast sodium 4 mg oral granules in healthy adults

Brief communication

Constanze Fey, Ursula Thyroff-Friesinger and Spencer Jones

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Clinical and Translational Allergy 2014, 4:29  doi:10.1186/2045-7022-4-29

Published: 18 September 2014

Demonstration of epinephrine autoinjectors (EpiPen and Anapen) by pharmacists in a randomised, simulated patient assessment: acceptable, but room for improvement

Research

Sandra M Salter, Richard Loh, Frank M Sanfilippo and Rhonda M Clifford

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Allergy, Asthma & Clinical Immunology 2014, 10:49  doi:10.1186/1710-1492-10-49

Published: 19 September 2014

Possible therapeutic potential of a recombinant group 2 grass pollen allergen-specific antibody fragment

Allergy. Author manuscript; available in PMC Aug 6, 2014.

Published in final edited form as:

Allergy. Feb 2014; 69(2): 261–264.

Published online Nov 20, 2013. doi:  10.1111/all.12315

PMCID: PMC4123173

EMSID: EMS59776

E. Gadermaier,¹ S. Flicker,¹ K. Blatt,² P. Valent,² and R. Valenta^1,3

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IgG4-related disease and its pathogenesis— cross-talk between innate and acquired immunity

Hisanori Umehara1,2,5, Akio Nakajima1, Takuji Nakamura1, Takafumi Kawanami1, Masao Tanaka1, Lingli Dong3 and Mitsuhiro Kawano4

+Author Affiliations

1. ¹ Department of Internal Medicine, Division of Hematology and Immunology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Kahoku-gun, Ishikawa 920-0293, Japan
2. ² Department of Clinical Immunology, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Kyoto 606-8501, Japan
3. ³ Department of Hematology and Immunology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
4. ⁴ Department of Internal Medicine, Division of Rheumatology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920-8641, Japan
5. ⁵Present address: Department of Clinical Immunology, Graduate School of Medicine and Faculty of Medicine, Kyoto University, Kyoto 606-8501, Japan

1. Correspondence to: H. Umehara; E-mail: umehara606@gmail.com

• Received October 26, 2013.
• Revision received July 2, 2014.
• Accepted July 3, 2014.

Dupilumab: a novel treatment for asthma

Alessandro Vatrella,¹ Immacolata Fabozzi,¹ Cecilia Calabrese,² Rosario Maselli,³ Girolamo Pelaia^3
1Department of Medicine and Surgery, University of Salerno, Salerno, ²Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, Naples, ³Department of Medical and Surgical Sciences, University Magna Græcia, Catanzaro, Italy