Long-acting muscarinic antagonist use in adults with asthma: real-life prescribing and outcomes of add-on therapy with tiotropium bromide

ORIGINAL RESEARCH

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Authors Price D, Kaplan A, Jones R, Freeman D, Burden A, Gould S, von Ziegenweidt J, Ali M, King C, Thomas M

Published Date January 2015 Volume 2015:8 Pages 1—13

DOI http://dx.doi.org/10.2147/JAA.S76639

Received 30 October 2014, Accepted 20 November 2014, Published 14 January 2015

Approved for publication by Dr Amrita Dosanjh

David Price,^1,2 Alan Kaplan,³ Rupert Jones,⁴ Daryl Freeman,⁵ Anne Burden,² Shuna Gould,² Julie von Ziegenweidt,² Muzammil Ali,² Christine King,² Mike Thomas^6
1Academic Centre of Primary Care, University of Aberdeen, Aberdeen, ²Research in Real-Life, Cambridge, UK; ³Family Physician Airways Group of Canada, Richmond Hill, ON, Canada; ⁴Centre for Clinical Trials and Health Research, Plymouth University, Plymouth, ⁵Norfolk Community Health and Care NHS Trust, Norwich, ⁶Primary Care Research, University of Southhampton, Southhampton, UK

Background: Randomized controlled trials indicate that addition of a long-acting muscarinic antagonist (LAMA) such as tiotropium may improve asthma control and reduce exacerbation risk in patients with poorly controlled asthma, but broader clinical studies are needed to investigate the effectiveness of LAMA in real-life asthma care.

Clinical similarities among bradykinin-mediated and mast cell-mediated subtypes of non-hereditary angioedema: a retrospective study

Research

Karlijn J G Schulkes^1†, Mignon T Van den Elzen^1*†, Erik C Hack¹², Henderikus G Otten²,Carla A F M Bruijnzeel-Koomen¹ and André C Knulst¹

Clinical and Translational Allergy 2015, 5:5  doi:10.1186/s13601-015-0049-8

Published: 4 February 2015

Abstract (provisional)

BackgroundNon-hereditary angioedema (non-HAE) is characterized by local swelling due to self-limiting, subcutaneous or submucosal extravasation of fluid, and can be divided into three subtypes.

Allergic drug reactions traced to single protein

Research from UAlberta and Johns Hopkins University points to new strategy to reduce allergic responses to multiple medications.

Priyanka Pundir and Marianna Kulka in the lab

Every day in hospitals around the world, patients suffer painful allergic reactions to the medicines they are given. The reactions, known as pseudo-allergies, often cause patients to endure itchiness, swelling and rashes as an unwanted part of their treatment plan. The reactions can be so severe they may stop patients from taking their needed medications and sometimes can even prove fatal. It’s never been shown conclusively what triggers these allergic reactions—until now.

Clinical Practice Guideline: Allergic Rhinitis

Michael D. Seidman, MD1, Richard K. Gurgel, MD2, Sandra Y. Lin, MD3, Seth R. Schwartz, MD, MPH4, Fuad M. Baroody, MD5, James R. Bonner, MD6, Douglas E. Dawson, MD7, Mark S. Dykewicz, MD8 , Jesse M. Hackell, MD9, Joseph K. Han, MD10, Stacey L. Ishman, MD, MPH11, Helene J. Krouse, PhD, ANP-BC, CORLN12, Sonya Malekzadeh, MD13, James (Whit) W. Mims, MD14, Folashade S. Omole, MD15, William D. Reddy, LAc, DiplAc16, Dana V. Wallace, MD17, Sandra A. Walsh18, Barbara E. Warren, PsyD, MEd18, Meghan N. Wilson, MD19, Lorraine C. Nnacheta, MPH20

SQ house dust mite sublingually administered immunotherapy tablet (ALK) improves allergic rhinitis in patients with house dust mite allergic asthma and rhinitis symptoms

February 2015 Volume 114, Issue 2, Pages 134–140.e1

Holger Mosbech, MD

, 

G. Walter Canonica, MD

, 

Vibeke Backer, MD

, 

Frederic de Blay, MD

, 

Ludger Klimek, MD

,

Louise Broge, PhD

, 

Christian Ljørring, MSc

Open Access

DOI: http://dx.doi.org/10.1016/j.anai.2014.11.015

Open access funded by the Author(s)

Article Info

Molecular Mechanisms of Nasal Epithelium in Rhinitis and Rhinosinusitis

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Abstract

Allergic rhinitis, nonallergic rhinitis, and chronic rhinosinusitis are multifactorial upper airway diseases with high prevalence. Several genetic and environmental factors are proposed to predispose to the pathogenesis of the inflammatory upper airway diseases. Still, the molecular mechanisms leading toward the onset and progression of upper airway diseases are largely unknown. The upper airway epithelium has an important role in sensing the environment and regulating the inhaled air. As such, it links environmental insults to the host immunity. Human sinonasal epithelium serves as an excellent target for observing induced early-phase events, in vivo, and with a systems biological perspective. Actually, increasing number of investigations have provided evidence that altered homeostasis in the sinonasal epithelium might be important in the chronic upper airway inflammation.

Keywords: 

Curr Allergy Asthma Rep. 2015; 15: 495.

Published online 2014 Dec 11. doi:  10.1007/s11882-014-0495-8

Sanna Toppila-Salmi, Cornelis M. van Drunen, Wytske J. Fokkens, Korneliuz Golebski, Pirkko Mattila, Sakari Joenvaara, Jutta Renkonen, and Risto Renkonen

Abstract

Allergic rhinitis, nonallergic rhinitis, and chronic rhinosinusitis are multifactorial upper airway diseases with high prevalence. Several genetic and environmental factors are proposed to predispose to the pathogenesis of the inflammatory upper airway diseases.

The Major Birch Pollen Allergen Bet v 1 Induces Different Responses in Dendritic Cells of Birch Pollen Allergic and Healthy Individuals

PLoS One. 2015 Jan 30;10(1):e0117904. doi: 10.1371/journal.pone.0117904. eCollection 2015.

Smole U1, Radauer C2, Lengger N2, Svoboda M2, Rigby N3, Bublin M2, Gaier S2, Hoffmann-Sommergruber K2, Jensen-Jarolim E4, Mechtcheriakova D2,Breiteneder H2.

Author information

Abstract

Dendritic cells play a fundamental role in shaping the immune response to allergens. The events that lead to allergic sensitization or tolerance induction during the interaction of the major birch pollen allergen Bet v 1 and dendritic cells are not very well studied.

Asian sand dust aggregate causes atopic dermatitis-like symptoms in Nc/Nga mice

Research

Sayaka Takeshita¹, Takahiro Tokunaga¹², Yoshiko Tanabe¹, Tadao Arinami¹, Takamichi Ichinose³ and Emiko Noguchi^14*

Allergy, Asthma & Clinical Immunology 2015, 11:3  doi:10.1186/s13223-015-0068-y

Published: 23 January 2015

Abstract

Background

Asian sand dust (ASD) originates from the arid and semiarid areas of China, and epidemiologic studies have shown that ASD exposure is associated with various allergic and respiratory symptoms. However, few studies have been performed to assess the relationship between skin inflammation and ASD exposure.

World Allergy Organization-McMaster University Guidelines for Allergic Disease Prevention (GLAD-P): Probiotics

Position article and guidelines

Alessandro Fiocchi^1†, Ruby Pawankar^2†, Carlos Cuello-Garcia³⁴, Kangmo Ahn⁵, Suleiman Al-Hammadi⁶, Arnav Agarwal³⁷, Kirsten Beyer⁸, Wesley Burks⁹, Giorgio W Canonica¹⁰,Motohiro Ebisawa¹¹, Shreyas Gandhi³⁷, Rose Kamenwa¹², Bee Wah Lee¹³, Haiqi Li¹⁴,Susan Prescott¹⁵, John J Riva¹⁶, Lanny Rosenwasser¹⁷, Hugh Sampson¹⁸, Michael Spigler¹⁹, Luigi Terracciano²⁰, Andrea Vereda-Ortiz²², Susan Waserman²¹, Juan José Yepes-Nuñez³, Jan L Brożek^213* and Holger J Schünemann²¹³

World Allergy Organization Journal 2015, 8:4  doi:10.1186/s40413-015-0055-2

Published: 27 January 2015

Abstract

Background

Prevalence of allergic diseases in infants, whose parents and siblings do not have allergy, is approximately 10% and reaches 20–30% in those with an allergic first-degree relative. Intestinal microbiota may modulate immunologic and inflammatory systemic responses and, thus, influence development of sensitization and allergy. Probiotics have been reported to modulate immune responses and their supplementation has been proposed as a preventive intervention.

Differences in the clinical and radiological characteristics of lung-involved toxocariasis between toxocariasis with eosinophilia and those without eosinophilia

 
• Vol 6, No 12 (December 2014) 

Authors: Bo Mi Park, Sang Ok Jeong, Hee Sun Park, Sung Soo Jung, Sun Young 

Kim, Ju Ock Kim, Jeong Eun Lee

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Abstract

Background: Previously, most studies did not discuss about the characteristics of lung-involved toxocariasis without eosinophilia. However, the patients are not always accompanied by eosinophilia, so it is necessary to learn about the clinical and radiologic features that may predict pulmonary toxocariasis without eosinophilia.