Drug Hypersensitivity: How Drugs Stimulate T Cells via Pharmacological Interaction with Immune Receptors

Vol. 168, No. 1, 2015 Issue release date: Published online first (Issue-in-Progress)

Pichler W.J.a · Adam J.a · Watkins S.c · Wuillemin N.b · Yun J.d · Yerly D.b 

aADR-AC GmbH, and bClinic of Rheumatology and Clinical Immunology/Allergology, University Hospital of Bern, Bern, Switzerland; cDepartment of Botany and Plant Pathology, Oregon State University, Corvallis, Oreg., USA; dDepartment of Clinical Immunology, Royal Prince Alfred Hospital, Sydney, N.S.W., Australia

Abstract

Small chemicals like drugs tend to bind to proteins via noncovalent bonds, e.g. hydrogen bonds, salt bridges or electrostatic interactions. Some chemicals interact with other molecules than the actual target ligand, representing so-called ‘off-target' activities of drugs.

Association of Early Exposure of Probiotics and Islet Autoimmunity in the TEDDY Study

JAMA Pediatr. Published online November 09, 2015. doi:10.1001/jamapediatrics.2015.2757

Ulla Uusitalo, PhD1; Xiang Liu, PhD1; Jimin Yang, PhD, RD1; Carin Andrén Aronsson, MS2; Sandra Hummel, PhD3; Martha Butterworth, MS1; Åke Lernmark, PhD2; Marian Rewers, PhD4; William Hagopian, MD, PhD5; Jin-Xiong She, PhD6; Olli Simell, MD, PhD7; Jorma Toppari, MD, PhD7,8; Anette G. Ziegler, PhD3; Beena Akolkar, PhD9; Jeffrey Krischer, PhD1; Jill M. Norris, PhD10; Suvi M. Virtanen, MD, PhD11,12,13 ; for the TEDDY Study Group

ABSTRACT

ABSTRACT | INTRODUCTION | METHODS | RESULTS | DISCUSSION | CONCLUSIONS | ARTICLE INFORMATION | REFERENCES

Importance  Probiotics have been hypothesized to affect immunologic responses to environmental exposures by supporting healthy gut microbiota and could therefore theoretically be used to prevent the development of type 1 diabetes mellitus (T1DM)–associated islet autoimmunity.

Objective  To examine the association between supplemental probiotic use during the first year of life and islet autoimmunity among children at increased genetic risk of T1DM.

Parental smoking and development of allergic sensitization from birth to adolescence

Allergy

Early View (Online Version of Record published before inclusion in an issue

1. J. D. Thacher^1,*, 
2. O. Gruzieva¹, 
3. G. Pershagen^1,2, 
4. Å. Neuman^1,3, 
5. M. van Hage⁴, 
6. M. Wickman^1,5, 
7. I. Kull^1,5,6, 
8. E. Melén^1,5and
9. A. Bergström¹

Abstract

Background

The relation between secondhand tobacco smoke (SHS) exposure and the development of allergic sensitization in children is unclear. The aim of this study was to determine whether maternal smoking during pregnancy and postnatal SHS exposure contributes to the development of allergic sensitization in children and adolescents up to 16 years of age.

Using Behavioral Insights to Increase Vaccination Policy Effectiveness

1. Cornelia Betsch⇑1, Robert Böhm2, Gretchen B. Chapman3

1. ¹University of Erfurt, Germany
2. ²RWTH Aachen University, Germany
3. ³Rutgers University, Piscataway, NJ, USA

1. Cornelia Betsch, Department of Psychology and Center for Empirical Research in Economics and Behavioral Sciences (CEREB), University of Erfurt, Nordhäuser Str. 63, 99089 Erfurt, Germany. Email: cornelia.betsch@uni-erfurt.de

Abstract

Even though there are policies in place, and safe and effective vaccines available, almost every country struggles with vaccine hesitancy, that is, a delay in acceptance or refusal of vaccination.

Characteristics and severity of asthma in children with and without atopic conditions: a cross-sectional study

Research article

Ali Arabkhazaeli¹, Susanne J. H. Vijverberg¹, Francine C. van Erp², Jan A. M. Raaijmakers¹, Cornelis K. van der Ent²and Anke H. Maitland van der Zee^1*

BMC Pediatrics 2015, 15:172  doi:10.1186/s12887-015-0481-x

Abstract

Background

Childhood allergic diseases have a major impact on a child’s quality of life, as well as that of their parents. We studied the coexistence of reported allergies in children who use asthma medication. Additionally, we tested the hypothesis that asthma severity is greater among children with certain combinations of co-morbid allergic conditions.

Prevalence and Spectrum of Gastro Esophageal Reflux Disease in Bronchial Asthma

 Volume : 9 | Issue : 10 | Page : OC11 - OC14

Sahoo Rameschandra, Vishak Acharya, Kunal, Tantry Vishwanath, Anand Ramkrishna, Preetam Acharya

Correspondence
Dr. Vishak Acharya,
Professor, HOD, Department of Pulmonary Medicine, Kasturba Medical College Hospital,
Attavara, Mangalore-575001, India.
E-mail : achvish@yahoo.co.in

Background: There exists a complex interplay between asthma and gastroesophageal reflux disease. Both these diseases are known to aggravate each other and amelioration of one is necessary for the control of the other. There is a paucity of studies in Indian population on this subject. 

Asthma and dietary intake: an overview of systematic reviews EAACI Diet, Lifestyle and Asthma Task Force

Allergy

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.

1. Vanessa Garcia-Larsen^1,*, 
2. Stefano R Del Giacco², 
3. André Moreira^3,4, 
4. Matteo Bonini⁵,
5. David Charles¹, 
6. Tim Reeves⁶, 
7. Kai-Håkon Carlsen⁷, 
8. Tari Haahtela⁸, 
9. Sergio Bonini⁹,
10. João Fonseca⁴, 
11. Ioana Agache¹⁰, 
12. Nikolaos G Papadopoulos¹¹ and
13. Luís Delgado^3,4

Abstract

Epidemiological research on the relationship between diet and asthma has increased in the last decade. Several components found in foods have been proposed to have a series of antioxidant, anti-allergic and anti-inflammatory properties, which can have a protective effect against asthma risk.

MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation

Allergy

Volume 70, Issue 11, pages 1372–1392, November 2015 

J. Bousquet, H. J. Schunemann, J. Fonseca et al. 

Abstract

Several unmet needs have been identified in allergic rhinitis: identification of the time of onset of the pollen season, optimal control of rhinitis and comorbidities, patient stratification, multidisciplinary team for integrated care pathways, innovation in clinical trials and, above all, patient empowerment.

360 degree perspective on allergic rhinitis management in Italy: a survey of GPs, pharmacists and patients

Research

G. Walter Canonica^1*, Massimo Triggiani² and GianEnrico Senna³

• *Corresponding author: G. W Canonica canonica@unige.it

Clinical and Molecular Allergy 2015, 13:25  doi:10.1186/s12948-015-0029-5

The electronic version of this article is the complete one and can be found online at:http://www.clinicalmolecularallergy.com/content/13/1/25

Abstract

Background

General practitioners (GPs), community pharmacists and allergic rhinitis (AR) patients in Italy were surveyed in order to gain insight from all three perspectives into the diagnosis, management and burden of AR in Italy.

Appropriateness of epinephrine use in ED patients with anaphylaxis

D.V. Baalmann

,

 J.B. Hagan

,

 J.T.C. Li

,

 E.P. Hess

,

 R.L. Campbell

Mayo Clinic, Rochester, MN

DOI: http://dx.doi.org/10.1016/j.annemergmed.2014.07.332

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• Abstract
• Full Text

Anaphylaxis is a potentially fatal allergic reaction that is most commonly treated in the emergency department (ED). Epinephrine is the treatment of choice for anaphylaxis.

Celiac disease and non-celiac gluten sensitivity

BMJ : British Medical Journal

BMJ. 2015 Oct 5;351:h4347. doi: 10.1136/bmj.h4347.

Lebwohl B1, Ludvigsson JF2, Green PH3

Abstract

Celiac disease is a multisystem immune based disorder that is triggered by the ingestion of gluten in genetically susceptible individuals. The prevalence of celiac disease has risen in recent decades and is currently about 1% in most Western populations.