Avascular necrosis after oral corticosteroids in otolaryngology: Case report and review of the literature

• Allergy Rhinol (Providence)
• v.7(1); Spring 2016
• PMC4837136

Allergy Rhinol (Providence). 2016 Spring; 7(1): e50–e54.

doi:  10.2500/ar.2016.7.0142

PMCID: PMC4837136

Patrick Kennedy, Jr., B.A.,1 Ahmed Bassiouni, M.B.B.S.,2 Alkis Psaltis, M.B.B.S.,3 Jastin Antisdel, M.D.,4 and Joseph Brunworth, M.D.4

Author information ► Copyright and License information ►

Abstract

Objective:

In this report, we present a rare case of avascular necrosis (AVN) in an otherwise healthy 42-year-old male patient treated with low dose oral corticosteroids for his bronchitis. A systematic review of the literature related to AVN and corticosteroids was performed.

Cow’s milk allergy in Dutch children: an epigenetic pilot survey

RESEARCH

 

OPEN ACCESS

• Nicole C. M. Petrus†Email author,
• Peter Henneman†,
• Andrea Venema,
• Adri Mul,
• Femke van Sinderen,
• Martin Haagmans,
• Olaf Mook,
• Raoul C. Hennekam,
• Aline B. Sprikkelman† and
• Marcel Mannens†

†Contributed equally

Clinical and Translational Allergy20166:16

DOI: 10.1186/s13601-016-0105-z

Abstract

Background

Cow’s milk allergy (CMA) is a common disease in infancy. Early environmental factors are likely to contribute to CMA. It is known that epigenetic gene regulation can be altered by environmental factors. We have set up a proof of concept study, aiming to detect epigenetic associations specific with CMA.

Multisystem reactions during egg oral food challenges may be associated with less severe reactions on initial presentation

LETTER TO THE EDITOR

 

OPEN ACCESS

• Girish Vitalpur†Email author,
• Ann Esquivel†,
• Kirsten M. Kloepfer,
• James E. Slaven and
• Frederick E. Leickly

†Contributed equally

Allergy, Asthma & Clinical Immunology201612:21

DOI: 10.1186/s13223-016-0125-1

Abstract

In this study, we assessed whether multisystem reactions to egg and extensively-heated (EH) egg during OFCs were associated with a history of multisystem reactions. Records of children, who underwent OFC to egg or EH egg over a five-year period were reviewed.

Cost Utility of Omalizumab Compared with Standard of Care for the Treatment of Chronic Spontaneous Urticaria

PharmacoEconomics

pp 1–13

Jonathan Graham, 

Doreen McBride, 

Donald Stull, 

Anna Halliday, 

Stamatia Theodora Alexopoulos, 

Maria-Magdalena Balp, 

Matthew Griffiths, 

Ion Agirrezabal, 

Torsten Zuberbier, 

Alan Brennan

Open Access  Article

DOI: 10.1007/s40273-016-0412-1

Abstract

Background

Chronic spontaneous urticaria (CSU) negatively impacts patient quality of life and productivity and is associated with considerable indirect costs to society.

Objective

The aim of this study was to assess the cost utility of add-on omalizumab treatment compared with standard of care (SOC) in moderate or severe CSU patients with inadequate response to SOC, from the UK societal perspective.

A new framework for the interpretation of IgE sensitization tests

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

DOI: 10.1111/all.12939

1. Graham Roberts^1,*, 
2. Markus Ollert², 
3. Rob Aalberse³, 
4. Moira Austin⁴, 
5. Adnan Custovic⁵, 
6. Audrey DunnGalvin⁶, 
7. Philippe A Eigenmann⁷, 
8. Filippo Fassio⁸, 
9. Clive Grattan⁹, 
10. Peter Hellings¹⁰, 
11. Jonathan Hourihane¹¹,
12. Edward Knol¹², 
13. Antonella Muraro¹³,
14. Nikolaos Papadopoulos^14,15, 
15. Alexandra F. Santos^16,17,18, 
16. Sabine Schnadt¹⁹and
17. Kassiani Tzeli¹⁵

• Abstract
• Cited By

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Abstract

IgE sensitization tests, such as skin prick testing and serum specific IgE, have been used to diagnose IgE-mediated clinical allergy for many years. Their prime drawback is that they detect sensitization which is only loosely related to clinical allergy. Many patients therefore require provocation tests to make a definitive diagnosis; these are often expensive and potentially associated with severe reactions.

Intralymphatic immunotherapy induces allergen specific plasmablasts and increases tolerance to skin prick testing in a pilot study

• • 
    
• • 
    
  Johannes Martin Schmid,
• Homaira Nezam,
• Hans Henrik Torp Madsen,
• Alexander Schmitz and
• Hans Jürgen HoffmannEmail author

Clinical and Translational Allergy20166:19

DOI: 10.1186/s13601-016-0107-x

Abstract

Background

Allergen Immunotherapy is a promising treatment of allergy. Seven patients with rhinoconjunctivitis to grass allergen were treated with intralymphatic immunotherapy (ILIT) to explore whether this treatment could be performed. Effect of treatment was assessed as change in symptom medication score, response in skin prick test and nasal allergen provocation. ILIT deposits allergen in an inguinal lymph node to elicit a strong immune stimulus. This allowed us to monitor appearance of allergen specific plasmablasts 7 days after allergen injection.

Primary immunodeficiencies associated with eosinophilia

• Behdad NavabiEmail author and
• Julia Elizabeth Mainwaring Upton

Allergy, Asthma & Clinical Immunology201612:27

DOI: 10.1186/s13223-016-0130-4

Abstract

Background

Eosinophilia is not an uncommon clinical finding. However, diagnosis of its cause can be a dilemma once common culprits, namely infection, allergy and reactive causes are excluded. Primary immunodeficiency disorders (PID) are among known differentials of eosinophilia. However, the list of PIDs typically reported with eosinophilia is small and the literature lacks an inclusive list of PIDs which have been reported with eosinophilia. This motivated us to review the literature for all PIDs which have been described to have elevated eosinophils as this may contribute to an earlier diagnosis of PID and further the understanding of eosinophilia.

ASSURE-CSU: a real-world study of burden of disease in patients with symptomatic chronic spontaneous urticaria

• Karsten WellerEmail author,
• Marcus Maurer,
• Clive Grattan,
• Alla Nakonechna,
• Mohamed Abuzakouk,
• Frédéric Bérard,
• Gordon Sussman,
• Ana M. Giménez-Arnau,
• Javier Ortiz de Frutos,
• André Knulst,
• G. Walter Canonica,
• Kelly Hollis,
• Doreen McBride and
• Maria-Magdalena Balp

Clinical and Translational Allergy20155:29

DOI: 10.1186/s13601-015-0072-9

©  Weller et al. 2015

Received: 27 April 2015

Accepted: 30 June 2015

Published: 17 August 2015

Abstract

Background

Chronic spontaneous urticaria (CSU) formerly known as chronic idiopathic urticaria (CIU) is a severe and distressing skin condition that remains uncontrolled in approximately one half of patients, despite the use of licensed, recommended doses of modern, second-generation H1-antihistamines. So far, the humanistic, societal and economic burden of CSU/CIU has not been well quantified. Therefore it is important to broaden our understanding of how CSU/CIU impacts patients, society, and healthcare systems, by determining the disease burden of CSU/CIU and the associated unmet need; as well as to further guide the use of new treatments in an efficient and cost-effective manner.

Viruses and bacteria in Th2 biased allergic airway disease

Accepted Article (Accepted, unedited articles published online and citable. The final edited and typeset version of record will appear in future.)

1. Feng Lan, 
2. Nan Zhang, 
3. Elien Gevaert,
4. Luo Zhang³ and
5. Claus Bachert

Abstract

Allergic airway diseases are typically characterized by a type 2-biased inflammation. Multiple distinct viruses and bacteria have been detected in the airways. Recently, it has been confirmed that the microbiome of allergic individuals differs from those of healthy subjects, showing a close relationship with the type 2 response in allergic airway disease.

Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity

Volume 71, Issue 5, pages 611–620, May 2016

1. D. Simon^1,‡,*, 
2. A. Cianferoni^2,3,‡, 
3. J. M. Spergel^2,3, 
4. S. Aceves⁴, 
5. M. Holbreich⁵, 
6. C. Venter^6,7, 
7. M. E. Rothenberg⁶, 
8. I. Terreehorst⁸, 
9. A. Muraro⁹, 
10. A. J. Lucendo¹⁰,
11. A. Schoepfer¹¹, 
12. A. Straumann¹² and
13. H.-U. Simon¹³

Abstract

Eosinophilic esophagitis (EoE) is a chronic disease characterized clinically by symptoms of esophageal dysfunction and histologically by eosinophil-predominant inflammation. EoE is frequently associated with concomitant atopic diseases and immunoglobulin E (IgE) sensitization to food allergens in children as well as to aeroallergens and cross-reactive plant allergen components in adults. Patients with EoE respond well to elemental and empirical food elimination diets.